Accounting for time dependence in large-scale multiple testing of event-related potential data1

Ching Fan Sheu, Émeline Perthame, Yuh Shiow Lee, David Causeur

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Event-related potentials (ERPs) are recordings of electrical activity along the scalp time-locked to perceptual, motor and cognitive events. Because ERP signals are often rare and weak, relative to the large between-subject variability, establishing significant associations between ERPs and behavioral (or experimental) variables of interest poses major challenges for statistical analysis. Noting that ERP time dependence exhibits a block pattern suggesting strong local and long-range autocorrelation components, we propose a flexible factor modeling of dependence. An adaptive factor adjustment procedure is derived from a joint estimation of the signal and noise processes, given a prior knowledge of the noise-alone intervals. A simulation study is presented using known signals embedded in a real dependence structure extracted from authentic ERP measurements. The proposed procedure performs well compared with existing multiple testing procedures and is more powerful at discovering interesting ERP features.

Original languageEnglish
Pages (from-to)219-245
Number of pages27
JournalAnnals of Applied Statistics
Issue number1
Publication statusPublished - 2016 Mar

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Statistics, Probability and Uncertainty


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