Acetaldehyde involvement in positive and negative alcohol expectancies in han Chinese persons with alcoholism

Cheng Yi Hahn, San Yuan Huang, Huei Chen Ko, Chau Hsiang Hsieh, I-Hui Lee, Tzung Lieh Yeh, Yen-Kuang Yang, Jia Fu Lee, Wei Wen Lin, Ru-Band Lu

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Context: The ALDH2*2 allele has been shown to be a protective factor against alcoholism in a normal population owing in part to the elevated blood level of acetaldehyde and its accompanying physiological discomforts after drinking alcohol. Despite the well-established link between the ALDH2*2 allele and the physiological discomforts after drinking, very little is known regarding the psychological expectancies of drinking among persons with alcoholism with different ALDH genotypes. Objectives: To determine whether there are differences in craving, alcohol consumption, and alcohol outcome expectancies between persons with alcoholism who have the ALDH2*1/*2 genotype and persons with alcoholism who have the ALDH2*1/*1 genotype. Design: Cross-sectional survey. Setting: Six outpatient alcohol treatment facilities in Taiwan. Participants: Ninety-eight persons with alcoholism who met the DSM-IV criteria for current alcohol dependence. Main Outcome Measures: Alcohol Craving Scale, Form 90, and Alcohol Expectancies Scale scores. Results: Overall, the ALDH2*1/*2 group had lower negative alcohol outcome expectancies (F4,93=2.43, P≤.05, ηp2=0.10). Specifically, they had fewer expected negative outcomes in the social or interpersonal domain (P<.05) and the emotional and physical domain (P≤.005) than did the ALDH2*1/*1 group. Moreover, the ALDH2*1/*2 group had higher positive alcohol outcome expectancies (F7,90=2.36, P<.05, ηp 2=0.16), and they had more expected positive outcomes in the relaxation and tension reduction domain (P<.05). The 2 groups did not differ in alcohol craving (P=.61) or consumption (P=.11). Conclusions: Although the ALDH2*2 allele has been associated with negative physiological responses in normal samples in past research, the psychological expectancies of drinking are more positive and less negative for persons with alcoholism who have the ALDH2*1/*2 genotype. A role of acetaldehyde is implied in these effects, which seem to override the usual discomfort effects associated with protection against alcohol drinking. Future studies are needed to assess alcohol outcome expectancies at different phases of alcohol dependence and to evaluate the concurrent relationships of blood levels of acetaldehyde with physiological and psychological outcomes among persons with alcoholism who have different ALDH genotypes.

Original languageEnglish
Pages (from-to)817-823
Number of pages7
JournalArchives of General Psychiatry
Volume63
Issue number7
DOIs
Publication statusPublished - 2006 Jul 12

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Acetaldehyde
Alcoholism
Alcohols
Genotype
Alcohol Drinking
Drinking
Alleles
Psychology
Expectancy
Person
Alcohol
Taiwan
Diagnostic and Statistical Manual of Mental Disorders
Outpatients
Cross-Sectional Studies
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Hahn, Cheng Yi ; Huang, San Yuan ; Ko, Huei Chen ; Hsieh, Chau Hsiang ; Lee, I-Hui ; Yeh, Tzung Lieh ; Yang, Yen-Kuang ; Lee, Jia Fu ; Lin, Wei Wen ; Lu, Ru-Band. / Acetaldehyde involvement in positive and negative alcohol expectancies in han Chinese persons with alcoholism. In: Archives of General Psychiatry. 2006 ; Vol. 63, No. 7. pp. 817-823.
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title = "Acetaldehyde involvement in positive and negative alcohol expectancies in han Chinese persons with alcoholism",
abstract = "Context: The ALDH2*2 allele has been shown to be a protective factor against alcoholism in a normal population owing in part to the elevated blood level of acetaldehyde and its accompanying physiological discomforts after drinking alcohol. Despite the well-established link between the ALDH2*2 allele and the physiological discomforts after drinking, very little is known regarding the psychological expectancies of drinking among persons with alcoholism with different ALDH genotypes. Objectives: To determine whether there are differences in craving, alcohol consumption, and alcohol outcome expectancies between persons with alcoholism who have the ALDH2*1/*2 genotype and persons with alcoholism who have the ALDH2*1/*1 genotype. Design: Cross-sectional survey. Setting: Six outpatient alcohol treatment facilities in Taiwan. Participants: Ninety-eight persons with alcoholism who met the DSM-IV criteria for current alcohol dependence. Main Outcome Measures: Alcohol Craving Scale, Form 90, and Alcohol Expectancies Scale scores. Results: Overall, the ALDH2*1/*2 group had lower negative alcohol outcome expectancies (F4,93=2.43, P≤.05, ηp2=0.10). Specifically, they had fewer expected negative outcomes in the social or interpersonal domain (P<.05) and the emotional and physical domain (P≤.005) than did the ALDH2*1/*1 group. Moreover, the ALDH2*1/*2 group had higher positive alcohol outcome expectancies (F7,90=2.36, P<.05, ηp 2=0.16), and they had more expected positive outcomes in the relaxation and tension reduction domain (P<.05). The 2 groups did not differ in alcohol craving (P=.61) or consumption (P=.11). Conclusions: Although the ALDH2*2 allele has been associated with negative physiological responses in normal samples in past research, the psychological expectancies of drinking are more positive and less negative for persons with alcoholism who have the ALDH2*1/*2 genotype. A role of acetaldehyde is implied in these effects, which seem to override the usual discomfort effects associated with protection against alcohol drinking. Future studies are needed to assess alcohol outcome expectancies at different phases of alcohol dependence and to evaluate the concurrent relationships of blood levels of acetaldehyde with physiological and psychological outcomes among persons with alcoholism who have different ALDH genotypes.",
author = "Hahn, {Cheng Yi} and Huang, {San Yuan} and Ko, {Huei Chen} and Hsieh, {Chau Hsiang} and I-Hui Lee and Yeh, {Tzung Lieh} and Yen-Kuang Yang and Lee, {Jia Fu} and Lin, {Wei Wen} and Ru-Band Lu",
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Acetaldehyde involvement in positive and negative alcohol expectancies in han Chinese persons with alcoholism. / Hahn, Cheng Yi; Huang, San Yuan; Ko, Huei Chen; Hsieh, Chau Hsiang; Lee, I-Hui; Yeh, Tzung Lieh; Yang, Yen-Kuang; Lee, Jia Fu; Lin, Wei Wen; Lu, Ru-Band.

In: Archives of General Psychiatry, Vol. 63, No. 7, 12.07.2006, p. 817-823.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Acetaldehyde involvement in positive and negative alcohol expectancies in han Chinese persons with alcoholism

AU - Hahn, Cheng Yi

AU - Huang, San Yuan

AU - Ko, Huei Chen

AU - Hsieh, Chau Hsiang

AU - Lee, I-Hui

AU - Yeh, Tzung Lieh

AU - Yang, Yen-Kuang

AU - Lee, Jia Fu

AU - Lin, Wei Wen

AU - Lu, Ru-Band

PY - 2006/7/12

Y1 - 2006/7/12

N2 - Context: The ALDH2*2 allele has been shown to be a protective factor against alcoholism in a normal population owing in part to the elevated blood level of acetaldehyde and its accompanying physiological discomforts after drinking alcohol. Despite the well-established link between the ALDH2*2 allele and the physiological discomforts after drinking, very little is known regarding the psychological expectancies of drinking among persons with alcoholism with different ALDH genotypes. Objectives: To determine whether there are differences in craving, alcohol consumption, and alcohol outcome expectancies between persons with alcoholism who have the ALDH2*1/*2 genotype and persons with alcoholism who have the ALDH2*1/*1 genotype. Design: Cross-sectional survey. Setting: Six outpatient alcohol treatment facilities in Taiwan. Participants: Ninety-eight persons with alcoholism who met the DSM-IV criteria for current alcohol dependence. Main Outcome Measures: Alcohol Craving Scale, Form 90, and Alcohol Expectancies Scale scores. Results: Overall, the ALDH2*1/*2 group had lower negative alcohol outcome expectancies (F4,93=2.43, P≤.05, ηp2=0.10). Specifically, they had fewer expected negative outcomes in the social or interpersonal domain (P<.05) and the emotional and physical domain (P≤.005) than did the ALDH2*1/*1 group. Moreover, the ALDH2*1/*2 group had higher positive alcohol outcome expectancies (F7,90=2.36, P<.05, ηp 2=0.16), and they had more expected positive outcomes in the relaxation and tension reduction domain (P<.05). The 2 groups did not differ in alcohol craving (P=.61) or consumption (P=.11). Conclusions: Although the ALDH2*2 allele has been associated with negative physiological responses in normal samples in past research, the psychological expectancies of drinking are more positive and less negative for persons with alcoholism who have the ALDH2*1/*2 genotype. A role of acetaldehyde is implied in these effects, which seem to override the usual discomfort effects associated with protection against alcohol drinking. Future studies are needed to assess alcohol outcome expectancies at different phases of alcohol dependence and to evaluate the concurrent relationships of blood levels of acetaldehyde with physiological and psychological outcomes among persons with alcoholism who have different ALDH genotypes.

AB - Context: The ALDH2*2 allele has been shown to be a protective factor against alcoholism in a normal population owing in part to the elevated blood level of acetaldehyde and its accompanying physiological discomforts after drinking alcohol. Despite the well-established link between the ALDH2*2 allele and the physiological discomforts after drinking, very little is known regarding the psychological expectancies of drinking among persons with alcoholism with different ALDH genotypes. Objectives: To determine whether there are differences in craving, alcohol consumption, and alcohol outcome expectancies between persons with alcoholism who have the ALDH2*1/*2 genotype and persons with alcoholism who have the ALDH2*1/*1 genotype. Design: Cross-sectional survey. Setting: Six outpatient alcohol treatment facilities in Taiwan. Participants: Ninety-eight persons with alcoholism who met the DSM-IV criteria for current alcohol dependence. Main Outcome Measures: Alcohol Craving Scale, Form 90, and Alcohol Expectancies Scale scores. Results: Overall, the ALDH2*1/*2 group had lower negative alcohol outcome expectancies (F4,93=2.43, P≤.05, ηp2=0.10). Specifically, they had fewer expected negative outcomes in the social or interpersonal domain (P<.05) and the emotional and physical domain (P≤.005) than did the ALDH2*1/*1 group. Moreover, the ALDH2*1/*2 group had higher positive alcohol outcome expectancies (F7,90=2.36, P<.05, ηp 2=0.16), and they had more expected positive outcomes in the relaxation and tension reduction domain (P<.05). The 2 groups did not differ in alcohol craving (P=.61) or consumption (P=.11). Conclusions: Although the ALDH2*2 allele has been associated with negative physiological responses in normal samples in past research, the psychological expectancies of drinking are more positive and less negative for persons with alcoholism who have the ALDH2*1/*2 genotype. A role of acetaldehyde is implied in these effects, which seem to override the usual discomfort effects associated with protection against alcohol drinking. Future studies are needed to assess alcohol outcome expectancies at different phases of alcohol dependence and to evaluate the concurrent relationships of blood levels of acetaldehyde with physiological and psychological outcomes among persons with alcoholism who have different ALDH genotypes.

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DO - 10.1001/archpsyc.63.7.817

M3 - Review article

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VL - 63

SP - 817

EP - 823

JO - JAMA Psychiatry

JF - JAMA Psychiatry

SN - 2168-622X

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