Acute myocardial infarction in young and very old Chinese adults: clinical characteristics and therapeutic implications

Jeng Kai Teng, Li Jen Lin, Liang-Miin Tsai, Chi Ming Kwan, Jyh Hong Chen

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Abstract

To characterize acute myocardial infarction (AMI) in young adults and octogenarians, 475 AMI patients, in age subsets, were examined. The clinical features, risk factors and in-hospital mortality were compared among 17 young patients (<40 years), 426 patients of common age (40-79 years), and 32 very elderly patients (≥80 years). The octogenarian patients were mainly female (male/female ratio, 0.9 vs. 4.7 in other subgroups, P < 0.005), and had more frequent atypical presentation and postinfarctional congestive heart failure; whereas infarct size, location and development of Q-wave, major arrhythmias and cardiac wall rupture were not different among these age subsets. The most common risk factors in the young group were dyslipidemia (67%) and cigarette smoking (65%), and in the octogenarian group were dyslipidemia (52%) and hypertension (50%). Among age subsets, however, the prevalence of risk factors was not significantly different except for a relatively lower smoking rate in the octogenarians. Compared with 40- to 79-year-old patients who had predominantly multi-vessel diseases, the young patients had milder coronary atherosclerosis and were more likely to have normal coronaries (27% vs. 5%, P < 0.01). Significantly more octogenarians than young patients succumbed to AMI in the hospital (44% vs. 18%, P < 0.005), usually because of a cardiogenic complication (93%). Also, the octogenarians were less likely than the younger patients to have received thrombolytic therapy, mostly because of delayed diagnosis and arrival at the hospital, or because of old age itself. The conclusion was that the octogenarian AMI patients comprise a high-mortality group who may benefit potentially from thrombolytic therapy, and should not be deprived of it because of old age alone.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalInternational Journal of Cardiology
Volume44
Issue number1
DOIs
Publication statusPublished - 1994 Mar 15

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Myocardial Infarction
Therapeutics
Thrombolytic Therapy
Dyslipidemias
Smoking
Heart Rupture
Delayed Diagnosis
Hospital Mortality
Cardiac Arrhythmias
Coronary Artery Disease
Young Adult
Heart Failure
Hypertension
Mortality

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Acute myocardial infarction in young and very old Chinese adults: clinical characteristics and therapeutic implications",
abstract = "To characterize acute myocardial infarction (AMI) in young adults and octogenarians, 475 AMI patients, in age subsets, were examined. The clinical features, risk factors and in-hospital mortality were compared among 17 young patients (<40 years), 426 patients of common age (40-79 years), and 32 very elderly patients (≥80 years). The octogenarian patients were mainly female (male/female ratio, 0.9 vs. 4.7 in other subgroups, P < 0.005), and had more frequent atypical presentation and postinfarctional congestive heart failure; whereas infarct size, location and development of Q-wave, major arrhythmias and cardiac wall rupture were not different among these age subsets. The most common risk factors in the young group were dyslipidemia (67{\%}) and cigarette smoking (65{\%}), and in the octogenarian group were dyslipidemia (52{\%}) and hypertension (50{\%}). Among age subsets, however, the prevalence of risk factors was not significantly different except for a relatively lower smoking rate in the octogenarians. Compared with 40- to 79-year-old patients who had predominantly multi-vessel diseases, the young patients had milder coronary atherosclerosis and were more likely to have normal coronaries (27{\%} vs. 5{\%}, P < 0.01). Significantly more octogenarians than young patients succumbed to AMI in the hospital (44{\%} vs. 18{\%}, P < 0.005), usually because of a cardiogenic complication (93{\%}). Also, the octogenarians were less likely than the younger patients to have received thrombolytic therapy, mostly because of delayed diagnosis and arrival at the hospital, or because of old age itself. The conclusion was that the octogenarian AMI patients comprise a high-mortality group who may benefit potentially from thrombolytic therapy, and should not be deprived of it because of old age alone.",
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Acute myocardial infarction in young and very old Chinese adults : clinical characteristics and therapeutic implications. / Teng, Jeng Kai; Lin, Li Jen; Tsai, Liang-Miin; Kwan, Chi Ming; Chen, Jyh Hong.

In: International Journal of Cardiology, Vol. 44, No. 1, 15.03.1994, p. 29-36.

Research output: Contribution to journalArticle

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