Acute Poisoning with Neonicotinoid Insecticides: A Case Report and Literature Review

Pei Chen Lin, Hung Jung Lin, Yu Ying Liao, How Ran Guo, Kuo Tai Chen

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Neonicotinoids are a new class of insecticides widely applied for crop protection. These insecticides act as agonists at nicotinic acetylcholine receptors, which cause insect paralysis and death. The high specificity for receptors in insects was considered to possess highly selective toxicity to insects and relative sparing of mammals. However, an increasing number of cases of acute neonicotinoid poisoning have been reported in recent years. We reported a man who developed respiratory failure and shock after ingestion of neonicotinoid insecticide. A detailed literature review found that respiratory, cardiovascular and certain neurological presentations are warning signs of severe neonicotinoid intoxication. The amounts of ingested neonicotinoid insecticide and the plasma neonicotinoid concentration are not useful guides for the management of intoxicated patients. Supportive treatment and decontamination are the practical methods for the management of all neonicotinoid-poisoned patients.

Original languageEnglish
Pages (from-to)282-286
Number of pages5
JournalBasic and Clinical Pharmacology and Toxicology
Volume112
Issue number4
DOIs
Publication statusPublished - 2013 Apr

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

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