Acute responses of bone specific and related markers to maximal eccentric exercise of the knee extensors and flexors in young men

Tsang Hai Huang, Jung Charng Lin, Mi Chia Ma, Tsung Yu, Trevor C. Chen

Research output: Contribution to journalArticle

Abstract

Objectives: The present study determined time-course changes in plasma bone-specific and -related markers following a bout of maximal eccentric contractions (MaxEC) of bilateral knee extensors (KE) and flexors (KF). Methods: Sedentary young men (n=30) performed a bout of 10 sets of 10 MaxEC (30°/s) of KE and KF with each leg, respectively. Maximal voluntary isometric contraction (MVC) torque, muscle soreness (SOR), plasma creatine kinase (CK) activity, insulin, leptin, tumor necrosis factor-α (TNF-α), undercarboxylated-osteocalcin (ucOCN), carboxy-terminal crosslinking telopeptide of type I collagen (CTX-1) and procollagen type I N-terminal propeptide (P1NP) concentrations were measured from before to 7 days after MaxEC. Results: Significant changes in MVC (KE: -28%, KF: -38%), SOR and plasma CK activity (peak: 39,163 IU/L) following MaxEC were evident (P<0.05) compared to baseline. Plasma leptin (17%) concentrations decreased at 1 day after MaxEC. In bone related markers, plasma ucOCN concentrations (20%) increased at 7 days after MaxEC, and plasma CTX-1 concentrations decreased at 2, 4 and 7 days after MaxEC (6~7%; P<0.05). Conclusion: These results demonstrate that a lean effect of bone generation and an enhanced energy anabolism can be induced by a single bout of MaxEC.

Original languageEnglish
Pages (from-to)206-215
Number of pages10
JournalJournal of Musculoskeletal Neuronal Interactions
Volume20
Issue number2
Publication statusPublished - 2020 Jun

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Orthopedics and Sports Medicine

Fingerprint Dive into the research topics of 'Acute responses of bone specific and related markers to maximal eccentric exercise of the knee extensors and flexors in young men'. Together they form a unique fingerprint.

  • Cite this