Addressable light-induced heat knockdown (aLINK) for caenorhabditis (C.) elegans immobilization

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Caenorhabditis (C.) elegans is an intriguing model animal. Often times, researchers may need to silence the squirming worms and brought them to various measurements. Here we present a method to rapidly silence the tiny animal by sublethal light-induced heat in a special microfluidic chip. The worm's neural functions are temporarily shut down when a threshold temperature is reached. The neural functions can be resumed once the heat is removed. A safe operating range as to inducing heat knockdown was investigated. The finding showed that well-controlled heat knockdown is autonomous, reversible, and potential to worm immobilization.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages365-367
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012 Jan 1
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 2012 Oct 282012 Nov 1

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period12-10-2812-11-01

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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