Adenoma‐carcinoma sequence: A reappraisal with immunohistochemical expression of ferritin

Hsiao‐Bai ‐B Yang, Ping‐I ‐I Hsu, Jen‐Chang ‐C Lee, Shih‐Huang ‐H Chan, Xi‐Zhang ‐Z Lin, Nan‐Haw ‐H Chow

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18 Citations (Scopus)


To examine the biological significance of ferritin (FRN) expression, a retrospective immunohistochemical study was performed in normal coIonic mucosae (n = 8), adenomas (n = 88), and colorectal carcinomas (n = 104). FRN was present in some epithelia in the crypt base of normal colonic mucosae. Significant cytoplasmic staining for FRN was revealed in 26 (29.5%) cases of adenoma and 54 cases (51.9%) of adenocarcinoma. The cancer cells had a higher proportion of FRN expression than those of adenomas or non‐neoplastic mucosae (P < 0.001). Expression of FRN showed a positive association with the degree of dysplasia (P = 0.039) and the distal location of adenoma (P = 0.013). FRN expression tended to be associated with the tumor size (P = 0.083), but no substantial difference was observed among the histologic types of adenoma (P = 0.754). The results suggest that cytoplasmic FRN expression is associated with cellular proliferation. The proliferative index shows a significant difference through the adenoma‐carcinoma sequence. Further investigation is necessary to clarify the clinical implication of FRN expression in tumor cells and normal‐appearing mucosae. © 1995 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalJournal of Surgical Oncology
Issue number1
Publication statusPublished - 1995 Sep

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology


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