Adenoma‐carcinoma sequence

A reappraisal with immunohistochemical expression of ferritin

Hsiao‐Bai ‐B Yang, Ping‐I ‐I Hsu, Jen‐Chang ‐C Lee, Shih-Huang Chan, Xi-Zhang Lin, Nan-Haw Chow

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To examine the biological significance of ferritin (FRN) expression, a retrospective immunohistochemical study was performed in normal coIonic mucosae (n = 8), adenomas (n = 88), and colorectal carcinomas (n = 104). FRN was present in some epithelia in the crypt base of normal colonic mucosae. Significant cytoplasmic staining for FRN was revealed in 26 (29.5%) cases of adenoma and 54 cases (51.9%) of adenocarcinoma. The cancer cells had a higher proportion of FRN expression than those of adenomas or non‐neoplastic mucosae (P < 0.001). Expression of FRN showed a positive association with the degree of dysplasia (P = 0.039) and the distal location of adenoma (P = 0.013). FRN expression tended to be associated with the tumor size (P = 0.083), but no substantial difference was observed among the histologic types of adenoma (P = 0.754). The results suggest that cytoplasmic FRN expression is associated with cellular proliferation. The proliferative index shows a significant difference through the adenoma‐carcinoma sequence. Further investigation is necessary to clarify the clinical implication of FRN expression in tumor cells and normal‐appearing mucosae. © 1995 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalJournal of Surgical Oncology
Volume60
Issue number1
DOIs
Publication statusPublished - 1995 Jan 1

Fingerprint

Ferritins
Adenoma
Mucous Membrane
Neoplasms
Colorectal Neoplasms
Adenocarcinoma
Epithelium
Retrospective Studies
Cell Proliferation
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

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title = "Adenoma‐carcinoma sequence: A reappraisal with immunohistochemical expression of ferritin",
abstract = "To examine the biological significance of ferritin (FRN) expression, a retrospective immunohistochemical study was performed in normal coIonic mucosae (n = 8), adenomas (n = 88), and colorectal carcinomas (n = 104). FRN was present in some epithelia in the crypt base of normal colonic mucosae. Significant cytoplasmic staining for FRN was revealed in 26 (29.5{\%}) cases of adenoma and 54 cases (51.9{\%}) of adenocarcinoma. The cancer cells had a higher proportion of FRN expression than those of adenomas or non‐neoplastic mucosae (P < 0.001). Expression of FRN showed a positive association with the degree of dysplasia (P = 0.039) and the distal location of adenoma (P = 0.013). FRN expression tended to be associated with the tumor size (P = 0.083), but no substantial difference was observed among the histologic types of adenoma (P = 0.754). The results suggest that cytoplasmic FRN expression is associated with cellular proliferation. The proliferative index shows a significant difference through the adenoma‐carcinoma sequence. Further investigation is necessary to clarify the clinical implication of FRN expression in tumor cells and normal‐appearing mucosae. {\circledC} 1995 Wiley‐Liss, Inc.",
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Adenoma‐carcinoma sequence : A reappraisal with immunohistochemical expression of ferritin. / Yang, Hsiao‐Bai ‐B; Hsu, Ping‐I ‐I; Lee, Jen‐Chang ‐C; Chan, Shih-Huang; Lin, Xi-Zhang; Chow, Nan-Haw.

In: Journal of Surgical Oncology, Vol. 60, No. 1, 01.01.1995, p. 35-40.

Research output: Contribution to journalArticle

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