TY - JOUR
T1 - Adenoma‐carcinoma sequence
T2 - A reappraisal with immunohistochemical expression of ferritin
AU - Yang, Hsiao‐Bai ‐B
AU - Hsu, Ping‐I ‐I
AU - Lee, Jen‐Chang ‐C
AU - Chan, Shih‐Huang ‐H
AU - Lin, Xi‐Zhang ‐Z
AU - Chow, Nan‐Haw ‐H
PY - 1995/9
Y1 - 1995/9
N2 - To examine the biological significance of ferritin (FRN) expression, a retrospective immunohistochemical study was performed in normal coIonic mucosae (n = 8), adenomas (n = 88), and colorectal carcinomas (n = 104). FRN was present in some epithelia in the crypt base of normal colonic mucosae. Significant cytoplasmic staining for FRN was revealed in 26 (29.5%) cases of adenoma and 54 cases (51.9%) of adenocarcinoma. The cancer cells had a higher proportion of FRN expression than those of adenomas or non‐neoplastic mucosae (P < 0.001). Expression of FRN showed a positive association with the degree of dysplasia (P = 0.039) and the distal location of adenoma (P = 0.013). FRN expression tended to be associated with the tumor size (P = 0.083), but no substantial difference was observed among the histologic types of adenoma (P = 0.754). The results suggest that cytoplasmic FRN expression is associated with cellular proliferation. The proliferative index shows a significant difference through the adenoma‐carcinoma sequence. Further investigation is necessary to clarify the clinical implication of FRN expression in tumor cells and normal‐appearing mucosae. © 1995 Wiley‐Liss, Inc.
AB - To examine the biological significance of ferritin (FRN) expression, a retrospective immunohistochemical study was performed in normal coIonic mucosae (n = 8), adenomas (n = 88), and colorectal carcinomas (n = 104). FRN was present in some epithelia in the crypt base of normal colonic mucosae. Significant cytoplasmic staining for FRN was revealed in 26 (29.5%) cases of adenoma and 54 cases (51.9%) of adenocarcinoma. The cancer cells had a higher proportion of FRN expression than those of adenomas or non‐neoplastic mucosae (P < 0.001). Expression of FRN showed a positive association with the degree of dysplasia (P = 0.039) and the distal location of adenoma (P = 0.013). FRN expression tended to be associated with the tumor size (P = 0.083), but no substantial difference was observed among the histologic types of adenoma (P = 0.754). The results suggest that cytoplasmic FRN expression is associated with cellular proliferation. The proliferative index shows a significant difference through the adenoma‐carcinoma sequence. Further investigation is necessary to clarify the clinical implication of FRN expression in tumor cells and normal‐appearing mucosae. © 1995 Wiley‐Liss, Inc.
UR - http://www.scopus.com/inward/record.url?scp=0029123509&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029123509&partnerID=8YFLogxK
U2 - 10.1002/jso.2930600108
DO - 10.1002/jso.2930600108
M3 - Article
C2 - 7545255
AN - SCOPUS:0029123509
VL - 60
SP - 35
EP - 40
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 1
ER -