Adenosine deaminase inhibitors. Synthesis and biological evaluation of chain modified analogs of (+)-EHNA

Palle V.P. Pragnacharyulu, Pei Jung Lu, Elie Abushanab

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Unsaturated chain modified analogs of (+)-EHNA have been prepared and evaluated as inhibitors of adenosine deaminase. The geometry appears to play a role in binding to the enzyme.

Original languageEnglish
Pages (from-to)2417-2420
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number20
DOIs
Publication statusPublished - 1996 Oct 22

Fingerprint

Adenosine Deaminase Inhibitors
Geometry
Enzymes
9-(2-hydroxy-3-nonyl)adenine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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title = "Adenosine deaminase inhibitors. Synthesis and biological evaluation of chain modified analogs of (+)-EHNA",
abstract = "Unsaturated chain modified analogs of (+)-EHNA have been prepared and evaluated as inhibitors of adenosine deaminase. The geometry appears to play a role in binding to the enzyme.",
author = "Pragnacharyulu, {Palle V.P.} and Lu, {Pei Jung} and Elie Abushanab",
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Adenosine deaminase inhibitors. Synthesis and biological evaluation of chain modified analogs of (+)-EHNA. / Pragnacharyulu, Palle V.P.; Lu, Pei Jung; Abushanab, Elie.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 20, 22.10.1996, p. 2417-2420.

Research output: Contribution to journalArticle

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AU - Pragnacharyulu, Palle V.P.

AU - Lu, Pei Jung

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