Adenosine deaminase inhibitors. Synthesis and biological evaluation of chain modified analogs of (+)-EHNA

Palle V.P. Pragnacharyulu; Pei Jung Lu; Elie Abushanab

doi:10.1016/0960-894X(96)00439-8

Adenosine deaminase inhibitors. Synthesis and biological evaluation of chain modified analogs of (+)-EHNA

Palle V.P. Pragnacharyulu, Pei Jung Lu, Elie Abushanab

Institute of Clinical Medicine

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Unsaturated chain modified analogs of (+)-EHNA have been prepared and evaluated as inhibitors of adenosine deaminase. The geometry appears to play a role in binding to the enzyme.

Original language	English
Pages (from-to)	2417-2420
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	20
DOIs	https://doi.org/10.1016/0960-894X(96)00439-8
Publication status	Published - 1996 Oct 22

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/0960-894X(96)00439-8

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title = "Adenosine deaminase inhibitors. Synthesis and biological evaluation of chain modified analogs of (+)-EHNA",

abstract = "Unsaturated chain modified analogs of (+)-EHNA have been prepared and evaluated as inhibitors of adenosine deaminase. The geometry appears to play a role in binding to the enzyme.",

author = "Pragnacharyulu, {Palle V.P.} and Lu, {Pei Jung} and Elie Abushanab",

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AU - Pragnacharyulu, Palle V.P.

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Adenosine deaminase inhibitors. Synthesis and biological evaluation of chain modified analogs of (+)-EHNA

Abstract

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