Adjuvant Radiotherapy After Keloid Excision: Preliminary Experience in Taiwan

Wei-Ting Hsueh, Kuo Shu Hung, Yu Chen Chen, Yen Tsung Huang, Chao-Kai Hsu, Rei Ogawa, Yuan-Yu Hsueh

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Surgical excision with adjuvant radiotherapy has gained attention as an effective treatment of keloid. The Asian population is challenged with a high incidence of keloid occurrence with a specific genetic predominance. The annual reported incidence of new keloid cases in Taiwan is around 30,000, but the disease control rate and effectiveness by means of surgical excision with adjuvant radiotherapy is not yet clear. METHODS: A retrospective chart review of the included consecutive keloid patients receiving surgical excision and radiotherapy was performed from 2013 to 2016 in a single institute. The reported risk factors were collected to investigate according to the outcome analysis. The Vancouver Scar Scale and the Japan Scar Workshop (JSW) Scar Scale were used to evaluate the correlation with keloid recurrence. RESULTS: In this series, the overall recurrence rate was 32%, reported with an average follow-up of 28 months. Independent risk factors varied according to the different outcome variables. Only JSW classification score independently predicted the risk of keloid recurrence (odds ratio, 1.305; P = 0.02). Both the Vancouver Scar Scale and the JSW system showed a good correlation with keloid recurrence (correlation efficiency, 0.529 and 0.54; P = 0.0437 and 0.0165, respectively). CONCLUSIONS: This preliminary report revealed convincing evidence of feasibility and effectiveness of applying adjuvant radiotherapy after keloid excision in the Taiwanese population. A more delicate biological equivalent dose of radiotherapy with an effective local control should be considered to improve the final outcome.

Original languageEnglish
Pages (from-to)S39-S44
JournalAnnals of plastic surgery
Volume82
Issue number1S Suppl 1
DOIs
Publication statusPublished - 2019 Jan 1

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Keloid
Adjuvant Radiotherapy
Taiwan
Cicatrix
Recurrence
Japan
Education
Radiotherapy
Incidence
Population
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Hsueh, Wei-Ting ; Hung, Kuo Shu ; Chen, Yu Chen ; Huang, Yen Tsung ; Hsu, Chao-Kai ; Ogawa, Rei ; Hsueh, Yuan-Yu. / Adjuvant Radiotherapy After Keloid Excision : Preliminary Experience in Taiwan. In: Annals of plastic surgery. 2019 ; Vol. 82, No. 1S Suppl 1. pp. S39-S44.
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abstract = "BACKGROUND: Surgical excision with adjuvant radiotherapy has gained attention as an effective treatment of keloid. The Asian population is challenged with a high incidence of keloid occurrence with a specific genetic predominance. The annual reported incidence of new keloid cases in Taiwan is around 30,000, but the disease control rate and effectiveness by means of surgical excision with adjuvant radiotherapy is not yet clear. METHODS: A retrospective chart review of the included consecutive keloid patients receiving surgical excision and radiotherapy was performed from 2013 to 2016 in a single institute. The reported risk factors were collected to investigate according to the outcome analysis. The Vancouver Scar Scale and the Japan Scar Workshop (JSW) Scar Scale were used to evaluate the correlation with keloid recurrence. RESULTS: In this series, the overall recurrence rate was 32{\%}, reported with an average follow-up of 28 months. Independent risk factors varied according to the different outcome variables. Only JSW classification score independently predicted the risk of keloid recurrence (odds ratio, 1.305; P = 0.02). Both the Vancouver Scar Scale and the JSW system showed a good correlation with keloid recurrence (correlation efficiency, 0.529 and 0.54; P = 0.0437 and 0.0165, respectively). CONCLUSIONS: This preliminary report revealed convincing evidence of feasibility and effectiveness of applying adjuvant radiotherapy after keloid excision in the Taiwanese population. A more delicate biological equivalent dose of radiotherapy with an effective local control should be considered to improve the final outcome.",
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Adjuvant Radiotherapy After Keloid Excision : Preliminary Experience in Taiwan. / Hsueh, Wei-Ting; Hung, Kuo Shu; Chen, Yu Chen; Huang, Yen Tsung; Hsu, Chao-Kai; Ogawa, Rei; Hsueh, Yuan-Yu.

In: Annals of plastic surgery, Vol. 82, No. 1S Suppl 1, 01.01.2019, p. S39-S44.

Research output: Contribution to journalArticle

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T2 - Preliminary Experience in Taiwan

AU - Hsueh, Wei-Ting

AU - Hung, Kuo Shu

AU - Chen, Yu Chen

AU - Huang, Yen Tsung

AU - Hsu, Chao-Kai

AU - Ogawa, Rei

AU - Hsueh, Yuan-Yu

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AB - BACKGROUND: Surgical excision with adjuvant radiotherapy has gained attention as an effective treatment of keloid. The Asian population is challenged with a high incidence of keloid occurrence with a specific genetic predominance. The annual reported incidence of new keloid cases in Taiwan is around 30,000, but the disease control rate and effectiveness by means of surgical excision with adjuvant radiotherapy is not yet clear. METHODS: A retrospective chart review of the included consecutive keloid patients receiving surgical excision and radiotherapy was performed from 2013 to 2016 in a single institute. The reported risk factors were collected to investigate according to the outcome analysis. The Vancouver Scar Scale and the Japan Scar Workshop (JSW) Scar Scale were used to evaluate the correlation with keloid recurrence. RESULTS: In this series, the overall recurrence rate was 32%, reported with an average follow-up of 28 months. Independent risk factors varied according to the different outcome variables. Only JSW classification score independently predicted the risk of keloid recurrence (odds ratio, 1.305; P = 0.02). Both the Vancouver Scar Scale and the JSW system showed a good correlation with keloid recurrence (correlation efficiency, 0.529 and 0.54; P = 0.0437 and 0.0165, respectively). CONCLUSIONS: This preliminary report revealed convincing evidence of feasibility and effectiveness of applying adjuvant radiotherapy after keloid excision in the Taiwanese population. A more delicate biological equivalent dose of radiotherapy with an effective local control should be considered to improve the final outcome.

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