Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan: clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene

Jiun-Ling Wang, Jann Tay Wang, Shey Ying Chen, Po Ren Hsueh, Hsiang Chi Kung, Yee Chun Chen, Shan Chwen Chang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

It is poorly defined whether or not adult patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia with a non-multi-resistant antibiogram phenotype and Panton-Valentine leukocidin (PVL) gene carriage have different clinical syndromes. Clinical characteristics of 95 adult patients of MRSA bacteremia, with isolates that were non-multi-resistant to non-β-lactam, were compared with a contemporaneous multiresistant group. Independent risk factors other than community-associated MRSA bacteremia patients associated with recovery of non-multi-resistant MRSA isolates by multivariate analysis included deep-seated infection and catheter insertion site infection. Older age, intensive care unit-onset bacteremia, and postoperative infection were negative independent risk factors associated with non-multi-resistant MRSA isolates. Most of the 60 recoverable non-multi-resistant MRSA isolates belonged to multilocus sequence type 59, and all isolates belonged to staphylococcal chromosomal cassette mec (SCCmec) element type IV or type V. Most PVL-positive MRSA isolates belonged to SCCmec V. PVL-positive CA-MRSA isolates could cause more deep-seated infections in patients presented with non-multi-resistant MRSA bacteremia.

Original languageEnglish
Pages (from-to)365-371
Number of pages7
JournalDiagnostic Microbiology and Infectious Disease
Volume59
Issue number4
DOIs
Publication statusPublished - 2007 Dec 1

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Microbial Sensitivity Tests
Methicillin-Resistant Staphylococcus aureus
Bacteremia
Taiwan
Genes
Infection
Panton-Valentine leukocidin
Lactams
Intensive Care Units
Multivariate Analysis
Catheters
Phenotype

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Wang, Jiun-Ling ; Wang, Jann Tay ; Chen, Shey Ying ; Hsueh, Po Ren ; Kung, Hsiang Chi ; Chen, Yee Chun ; Chang, Shan Chwen. / Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan : clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene. In: Diagnostic Microbiology and Infectious Disease. 2007 ; Vol. 59, No. 4. pp. 365-371.
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Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan : clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene. / Wang, Jiun-Ling; Wang, Jann Tay; Chen, Shey Ying; Hsueh, Po Ren; Kung, Hsiang Chi; Chen, Yee Chun; Chang, Shan Chwen.

In: Diagnostic Microbiology and Infectious Disease, Vol. 59, No. 4, 01.12.2007, p. 365-371.

Research output: Contribution to journalArticle

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