Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan: clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene

Jiun Ling Wang; Jann Tay Wang; Shey Ying Chen; Po Ren Hsueh; Hsiang Chi Kung; Yee Chun Chen; Shan Chwen Chang

doi:10.1016/j.diagmicrobio.2007.06.021

Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan: clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene

Jiun Ling Wang, Jann Tay Wang, Shey Ying Chen, Po Ren Hsueh, Hsiang Chi Kung, Yee Chun Chen, Shan Chwen Chang

Department of Internal Medicine(NCKUH)

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

It is poorly defined whether or not adult patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia with a non-multi-resistant antibiogram phenotype and Panton-Valentine leukocidin (PVL) gene carriage have different clinical syndromes. Clinical characteristics of 95 adult patients of MRSA bacteremia, with isolates that were non-multi-resistant to non-β-lactam, were compared with a contemporaneous multiresistant group. Independent risk factors other than community-associated MRSA bacteremia patients associated with recovery of non-multi-resistant MRSA isolates by multivariate analysis included deep-seated infection and catheter insertion site infection. Older age, intensive care unit-onset bacteremia, and postoperative infection were negative independent risk factors associated with non-multi-resistant MRSA isolates. Most of the 60 recoverable non-multi-resistant MRSA isolates belonged to multilocus sequence type 59, and all isolates belonged to staphylococcal chromosomal cassette mec (SCCmec) element type IV or type V. Most PVL-positive MRSA isolates belonged to SCCmec V. PVL-positive CA-MRSA isolates could cause more deep-seated infections in patients presented with non-multi-resistant MRSA bacteremia.

Original language	English
Pages (from-to)	365-371
Number of pages	7
Journal	Diagnostic Microbiology and Infectious Disease
Volume	59
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2007.06.021
Publication status	Published - 2007 Dec

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diagmicrobio.2007.06.021

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Wang, J. L., Wang, J. T., Chen, S. Y., Hsueh, P. R., Kung, H. C., Chen, Y. C., & Chang, S. C. (2007). Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan: clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene. Diagnostic Microbiology and Infectious Disease, 59(4), 365-371. https://doi.org/10.1016/j.diagmicrobio.2007.06.021

@article{c371d120a08341f8a0bd28419e0ad42c,

title = "Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan: clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene",

abstract = "It is poorly defined whether or not adult patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia with a non-multi-resistant antibiogram phenotype and Panton-Valentine leukocidin (PVL) gene carriage have different clinical syndromes. Clinical characteristics of 95 adult patients of MRSA bacteremia, with isolates that were non-multi-resistant to non-β-lactam, were compared with a contemporaneous multiresistant group. Independent risk factors other than community-associated MRSA bacteremia patients associated with recovery of non-multi-resistant MRSA isolates by multivariate analysis included deep-seated infection and catheter insertion site infection. Older age, intensive care unit-onset bacteremia, and postoperative infection were negative independent risk factors associated with non-multi-resistant MRSA isolates. Most of the 60 recoverable non-multi-resistant MRSA isolates belonged to multilocus sequence type 59, and all isolates belonged to staphylococcal chromosomal cassette mec (SCCmec) element type IV or type V. Most PVL-positive MRSA isolates belonged to SCCmec V. PVL-positive CA-MRSA isolates could cause more deep-seated infections in patients presented with non-multi-resistant MRSA bacteremia.",

author = "Wang, {Jiun Ling} and Wang, {Jann Tay} and Chen, {Shey Ying} and Hsueh, {Po Ren} and Kung, {Hsiang Chi} and Chen, {Yee Chun} and Chang, {Shan Chwen}",

note = "Funding Information: This study was supported by grants from the National Science Council in Taiwan (NSC 94-2314-B-002-184).",

year = "2007",

month = dec,

doi = "10.1016/j.diagmicrobio.2007.06.021",

language = "English",

volume = "59",

pages = "365--371",

journal = "Diagnostic Microbiology and Infectious Disease",

issn = "0732-8893",

publisher = "Elsevier Inc.",

number = "4",

}

Wang, JL, Wang, JT, Chen, SY, Hsueh, PR, Kung, HC, Chen, YC & Chang, SC 2007, 'Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan: clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene', Diagnostic Microbiology and Infectious Disease, vol. 59, no. 4, pp. 365-371. https://doi.org/10.1016/j.diagmicrobio.2007.06.021

Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan: clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene. / Wang, Jiun Ling; Wang, Jann Tay; Chen, Shey Ying et al.
In: Diagnostic Microbiology and Infectious Disease, Vol. 59, No. 4, 12.2007, p. 365-371.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan

T2 - clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene

AU - Wang, Jiun Ling

AU - Wang, Jann Tay

AU - Chen, Shey Ying

AU - Hsueh, Po Ren

AU - Kung, Hsiang Chi

AU - Chen, Yee Chun

AU - Chang, Shan Chwen

N1 - Funding Information: This study was supported by grants from the National Science Council in Taiwan (NSC 94-2314-B-002-184).

PY - 2007/12

Y1 - 2007/12

N2 - It is poorly defined whether or not adult patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia with a non-multi-resistant antibiogram phenotype and Panton-Valentine leukocidin (PVL) gene carriage have different clinical syndromes. Clinical characteristics of 95 adult patients of MRSA bacteremia, with isolates that were non-multi-resistant to non-β-lactam, were compared with a contemporaneous multiresistant group. Independent risk factors other than community-associated MRSA bacteremia patients associated with recovery of non-multi-resistant MRSA isolates by multivariate analysis included deep-seated infection and catheter insertion site infection. Older age, intensive care unit-onset bacteremia, and postoperative infection were negative independent risk factors associated with non-multi-resistant MRSA isolates. Most of the 60 recoverable non-multi-resistant MRSA isolates belonged to multilocus sequence type 59, and all isolates belonged to staphylococcal chromosomal cassette mec (SCCmec) element type IV or type V. Most PVL-positive MRSA isolates belonged to SCCmec V. PVL-positive CA-MRSA isolates could cause more deep-seated infections in patients presented with non-multi-resistant MRSA bacteremia.

AB - It is poorly defined whether or not adult patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia with a non-multi-resistant antibiogram phenotype and Panton-Valentine leukocidin (PVL) gene carriage have different clinical syndromes. Clinical characteristics of 95 adult patients of MRSA bacteremia, with isolates that were non-multi-resistant to non-β-lactam, were compared with a contemporaneous multiresistant group. Independent risk factors other than community-associated MRSA bacteremia patients associated with recovery of non-multi-resistant MRSA isolates by multivariate analysis included deep-seated infection and catheter insertion site infection. Older age, intensive care unit-onset bacteremia, and postoperative infection were negative independent risk factors associated with non-multi-resistant MRSA isolates. Most of the 60 recoverable non-multi-resistant MRSA isolates belonged to multilocus sequence type 59, and all isolates belonged to staphylococcal chromosomal cassette mec (SCCmec) element type IV or type V. Most PVL-positive MRSA isolates belonged to SCCmec V. PVL-positive CA-MRSA isolates could cause more deep-seated infections in patients presented with non-multi-resistant MRSA bacteremia.

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U2 - 10.1016/j.diagmicrobio.2007.06.021

DO - 10.1016/j.diagmicrobio.2007.06.021

M3 - Article

C2 - 17878063

AN - SCOPUS:36549081308

SN - 0732-8893

VL - 59

SP - 365

EP - 371

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 4

ER -

Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan: clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene

Abstract

All Science Journal Classification (ASJC) codes

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