Advances in Noninvasive Functional Imaging of Bone

Sheng-Min Lan, Ya Na Wu, Ping-Ching Wu, Chi Kuang Sun, Dar-Bin Shieh, Ruey Mo Lin

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The demand for functional imaging in clinical medicine is comprehensive. Although the gold standard for the functional imaging of human bones in clinical settings is still radionuclide-based imaging modalities, nonionizing noninvasive imaging technology in small animals has greatly advanced in recent decades, especially the diffuse optical imaging to which Britton Chance made tremendous contributions. The evolution of imaging probes, instruments, and computation has facilitated exploration in the complicated biomedical research field by allowing longitudinal observation of molecular events in live cells and animals. These research-imaging tools are being used for clinical applications in various specialties, such as oncology, neuroscience, and dermatology. The Bone, a deeply located mineralized tissue, presents a challenge for noninvasive functional imaging in humans. Using nanoparticles (NP) with multiple favorable properties as bioimaging probes has provided orthopedics an opportunity to benefit from these noninvasive bone-imaging techniques. This review highlights the historical evolution of radionuclide-based imaging, computed tomography, positron emission tomography, and magnetic resonance imaging, diffuse optics-enabled in vivo technologies, vibrational spectroscopic imaging, and a greater potential for using NPs for biomedical imaging.

Original languageEnglish
Pages (from-to)281-301
Number of pages21
JournalAcademic Radiology
Volume21
Issue number2
DOIs
Publication statusPublished - 2014 Feb 1

Fingerprint

Bone and Bones
Radionuclide Imaging
Technology
Optical Imaging
Clinical Medicine
Neurosciences
Dermatology
Nanoparticles
Orthopedics
Biomedical Research
Magnetic Resonance Imaging
Observation
Research
Positron Emission Tomography Computed Tomography

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Lan, Sheng-Min ; Wu, Ya Na ; Wu, Ping-Ching ; Sun, Chi Kuang ; Shieh, Dar-Bin ; Lin, Ruey Mo. / Advances in Noninvasive Functional Imaging of Bone. In: Academic Radiology. 2014 ; Vol. 21, No. 2. pp. 281-301.
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Advances in Noninvasive Functional Imaging of Bone. / Lan, Sheng-Min; Wu, Ya Na; Wu, Ping-Ching; Sun, Chi Kuang; Shieh, Dar-Bin; Lin, Ruey Mo.

In: Academic Radiology, Vol. 21, No. 2, 01.02.2014, p. 281-301.

Research output: Contribution to journalReview article

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