TY - JOUR
T1 - Against the NEER principle
T2 - The third type of photochromism for GFP chromophore derivatives
AU - Liao, Jun Wei
AU - Sung, Robert
AU - Sung, Kuangsen
N1 - Funding Information:
We thank the National Science Council of Taiwan for financial support (NSC109-2113-M-006-005) and the National Center for High-performance Computing for computer facilities and time.
Publisher Copyright:
© the Owner Societies 2021.
PY - 2022/1/7
Y1 - 2022/1/7
N2 - Photochromism is the heart of photochromic fluorescent proteins. Excited-state proton transfer (ESPT) is the major cause of photochromism for the green fluorescent protein (GFP) andZ-Ephotoisomerization through τ-torsion is the major cause of photochromism for Dronpa (a GFP mutant). In this article,s-E-1opens a third type of photochromism for GFP chromophore derivatives, which involves light-driven φ-torsion with no τ-torsion, followed by excited-state intramolecular proton transfer (ESIPT), and is gated by environmental polarity. Sinces-E-1does not followZ-Ephotoisomerization through τ-torsion but undergoes light-driven φ-torsion, which involves equilibration of the excited-state rotamers, it is clearly against the NEER (Non-Equilibration of Excited-state Rotamers) principle.
AB - Photochromism is the heart of photochromic fluorescent proteins. Excited-state proton transfer (ESPT) is the major cause of photochromism for the green fluorescent protein (GFP) andZ-Ephotoisomerization through τ-torsion is the major cause of photochromism for Dronpa (a GFP mutant). In this article,s-E-1opens a third type of photochromism for GFP chromophore derivatives, which involves light-driven φ-torsion with no τ-torsion, followed by excited-state intramolecular proton transfer (ESIPT), and is gated by environmental polarity. Sinces-E-1does not followZ-Ephotoisomerization through τ-torsion but undergoes light-driven φ-torsion, which involves equilibration of the excited-state rotamers, it is clearly against the NEER (Non-Equilibration of Excited-state Rotamers) principle.
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U2 - 10.1039/d1cp03581a
DO - 10.1039/d1cp03581a
M3 - Article
C2 - 34889318
AN - SCOPUS:85121860801
SN - 1463-9076
VL - 24
SP - 295
EP - 304
JO - Physical Chemistry Chemical Physics
JF - Physical Chemistry Chemical Physics
IS - 1
ER -