Age at onset of type 1 diabetes between puberty and 30 years old is associated with increased diabetic nephropathy risk

Yen Bo Lin; Tien Jyun Chang; Wayne Huey Herng Sheu; Su Huey Lo; Yen Po Yeh; Chien Ning Huang; Chii Min Hwu; Chang Hsun Hsieh; Horng Yi Ou; Lee Ming Chuang; Jung Fu Chen; Yu Cheng Chen; Yun Hsing Peng; Szu Tah Chen; Shang Ren Hsu; Yi Ling Hsieh; Chih Hsun Chu; Chieg Hsiang Lu; Yau Jiunn Lee; Hua Fen Chen; Ching Chu Chen; Chun Chuan Lee; Pi Jung Hsiao; Shih Tzer Tsai; Samuel Chen; Ching Chieh Su; Yu Ling Lin; Cho Tsan Bau; Chung Chia Liao; Tsung Yung Kuo; Huey Jen Chen; Chih Chien Wang; Chiu Jung Cheng; Yung Lung Lin; Shin Chueh Chen; Chung Yuan Chen; Hsin Yang Huang; Jiunn Rong Chen; Hsiao Jung Lo; Neng Chun Yu; Wen Cheng Liu; Chun Han Wu; Deng Wang Chen; De Chung Shen; Wei Chen Chung

doi:10.1038/s41598-024-54137-2

Age at onset of type 1 diabetes between puberty and 30 years old is associated with increased diabetic nephropathy risk

Yen Bo Lin, Tien Jyun Chang, Wayne Huey Herng Sheu, Su Huey Lo, Yen Po Yeh, Chien Ning Huang, Chii Min Hwu, Chang Hsun Hsieh, Horng Yi Ou, Lee Ming Chuang, Jung Fu Chen, Yu Cheng Chen, Yun Hsing Peng, Szu Tah Chen, Shang Ren Hsu, Yi Ling Hsieh, Chih Hsun Chu, Chieg Hsiang Lu, Yau Jiunn Lee, Hua Fen ChenChing Chu Chen, Chun Chuan Lee, Pi Jung Hsiao, Shih Tzer Tsai, Samuel Chen, Ching Chieh Su, Yu Ling Lin, Cho Tsan Bau, Chung Chia Liao, Tsung Yung Kuo, Huey Jen Chen, Chih Chien Wang, Chiu Jung Cheng, Yung Lung Lin, Shin Chueh Chen, Chung Yuan Chen, Hsin Yang Huang, Jiunn Rong Chen, Hsiao Jung Lo, Neng Chun Yu, Wen Cheng Liu, Chun Han Wu, Deng Wang Chen, De Chung Shen, Wei Chen Chung

Department of Internal Medicine

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Abstract

Diabetic nephropathy is a critical complication of patients with type 1 diabetes, while epidemiological studies were scarce among Asian countries. We conducted a cross-sectional study to identify factors associated with diabetic nephropathy by questionnaires, using student’s t-test, chi-square test, and multivariable logistic regression. Among 898 participants, 16.7% had diabetic nephropathy. Compared with non-diabetic nephropathy patients, the patients with diabetic nephropathy had significantly higher percentage with onset age of type 1 diabetes between puberty and under 30 years old (female ≥ 12 or male ≥ 13 years old to 29 years old), longer diabetes duration, having family history of diabetes and diabetic nephropathy, accompanied with hypertension, hyperlipidemia, or coronary artery disease (CAD). Compared with patients with onset age before puberty, the odds of diabetic nephropathy occurrence increased to 1.61 times in patients with onset age between puberty and under 30 years old (p = 0.012) after adjusting diabetes duration. Age of diabetes onset between puberty and under 30 years old, diabetes duration, HbA1c, hospital admission within 3 years, diabetic retinopathy, hypertension, systolic blood pressure (SBP), triglyceride levels, and use of angiotensin converting enzyme inhibitor (ACEI) and/or angiotensin receptor blockers (ARB) were independent factors associated with diabetic nephropathy Screening for proteinuria is important in daily clinical practice and should be part of diabetes self-management education for patients with type 1 diabetes.

Original language	English
Article number	3611
Journal	Scientific reports
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/s41598-024-54137-2
Publication status	Published - 2024 Dec

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10.1038/s41598-024-54137-2

Cite this

Lin, Y. B., Chang, T. J., Sheu, W. H. H., Lo, S. H., Yeh, Y. P., Huang, C. N., Hwu, C. M., Hsieh, C. H., Ou, H. Y., Chuang, L. M., Chen, J. F., Chen, Y. C., Peng, Y. H., Chen, S. T., Hsu, S. R., Hsieh, Y. L., Chu, C. H., Lu, C. H., Lee, Y. J., ... Chung, W. C. (2024). Age at onset of type 1 diabetes between puberty and 30 years old is associated with increased diabetic nephropathy risk. Scientific reports, 14(1), Article 3611. https://doi.org/10.1038/s41598-024-54137-2

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title = "Age at onset of type 1 diabetes between puberty and 30 years old is associated with increased diabetic nephropathy risk",

abstract = "Diabetic nephropathy is a critical complication of patients with type 1 diabetes, while epidemiological studies were scarce among Asian countries. We conducted a cross-sectional study to identify factors associated with diabetic nephropathy by questionnaires, using student{\textquoteright}s t-test, chi-square test, and multivariable logistic regression. Among 898 participants, 16.7% had diabetic nephropathy. Compared with non-diabetic nephropathy patients, the patients with diabetic nephropathy had significantly higher percentage with onset age of type 1 diabetes between puberty and under 30 years old (female ≥ 12 or male ≥ 13 years old to 29 years old), longer diabetes duration, having family history of diabetes and diabetic nephropathy, accompanied with hypertension, hyperlipidemia, or coronary artery disease (CAD). Compared with patients with onset age before puberty, the odds of diabetic nephropathy occurrence increased to 1.61 times in patients with onset age between puberty and under 30 years old (p = 0.012) after adjusting diabetes duration. Age of diabetes onset between puberty and under 30 years old, diabetes duration, HbA1c, hospital admission within 3 years, diabetic retinopathy, hypertension, systolic blood pressure (SBP), triglyceride levels, and use of angiotensin converting enzyme inhibitor (ACEI) and/or angiotensin receptor blockers (ARB) were independent factors associated with diabetic nephropathy Screening for proteinuria is important in daily clinical practice and should be part of diabetes self-management education for patients with type 1 diabetes.",

author = "Lin, {Yen Bo} and Chang, {Tien Jyun} and Sheu, {Wayne Huey Herng} and Lo, {Su Huey} and Yeh, {Yen Po} and Huang, {Chien Ning} and Hwu, {Chii Min} and Hsieh, {Chang Hsun} and Ou, {Horng Yi} and Chuang, {Lee Ming} and Chen, {Jung Fu} and Chen, {Yu Cheng} and Peng, {Yun Hsing} and Chen, {Szu Tah} and Hsu, {Shang Ren} and Hsieh, {Yi Ling} and Chu, {Chih Hsun} and Lu, {Chieg Hsiang} and Lee, {Yau Jiunn} and Chen, {Hua Fen} and Chen, {Ching Chu} and Lee, {Chun Chuan} and Hsiao, {Pi Jung} and Tsai, {Shih Tzer} and Samuel Chen and Su, {Ching Chieh} and Lin, {Yu Ling} and Bau, {Cho Tsan} and Liao, {Chung Chia} and Kuo, {Tsung Yung} and Chen, {Huey Jen} and Wang, {Chih Chien} and Cheng, {Chiu Jung} and Lin, {Yung Lung} and Chen, {Shin Chueh} and Chen, {Chung Yuan} and Huang, {Hsin Yang} and Chen, {Jiunn Rong} and Lo, {Hsiao Jung} and Yu, {Neng Chun} and Liu, {Wen Cheng} and Wu, {Chun Han} and Chen, {Deng Wang} and Shen, {De Chung} and Chung, {Wei Chen}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1038/s41598-024-54137-2",

language = "English",

volume = "14",

journal = "Scientific reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

Lin, YB, Chang, TJ, Sheu, WHH, Lo, SH, Yeh, YP, Huang, CN, Hwu, CM, Hsieh, CH, Ou, HY, Chuang, LM, Chen, JF, Chen, YC, Peng, YH, Chen, ST, Hsu, SR, Hsieh, YL, Chu, CH, Lu, CH, Lee, YJ, Chen, HF, Chen, CC, Lee, CC, Hsiao, PJ, Tsai, ST, Chen, S, Su, CC, Lin, YL, Bau, CT, Liao, CC, Kuo, TY, Chen, HJ, Wang, CC, Cheng, CJ, Lin, YL, Chen, SC, Chen, CY, Huang, HY, Chen, JR, Lo, HJ, Yu, NC, Liu, WC, Wu, CH, Chen, DW, Shen, DC & Chung, WC 2024, 'Age at onset of type 1 diabetes between puberty and 30 years old is associated with increased diabetic nephropathy risk', Scientific reports, vol. 14, no. 1, 3611. https://doi.org/10.1038/s41598-024-54137-2

TY - JOUR

T1 - Age at onset of type 1 diabetes between puberty and 30 years old is associated with increased diabetic nephropathy risk

AU - Lin, Yen Bo

AU - Chang, Tien Jyun

AU - Sheu, Wayne Huey Herng

AU - Lo, Su Huey

AU - Yeh, Yen Po

AU - Huang, Chien Ning

AU - Hwu, Chii Min

AU - Hsieh, Chang Hsun

AU - Ou, Horng Yi

AU - Chuang, Lee Ming

AU - Chen, Jung Fu

AU - Chen, Yu Cheng

AU - Peng, Yun Hsing

AU - Chen, Szu Tah

AU - Hsu, Shang Ren

AU - Hsieh, Yi Ling

AU - Chu, Chih Hsun

AU - Lu, Chieg Hsiang

AU - Lee, Yau Jiunn

AU - Chen, Hua Fen

AU - Chen, Ching Chu

AU - Lee, Chun Chuan

AU - Hsiao, Pi Jung

AU - Tsai, Shih Tzer

AU - Chen, Samuel

AU - Su, Ching Chieh

AU - Lin, Yu Ling

AU - Bau, Cho Tsan

AU - Liao, Chung Chia

AU - Kuo, Tsung Yung

AU - Chen, Huey Jen

AU - Wang, Chih Chien

AU - Cheng, Chiu Jung

AU - Lin, Yung Lung

AU - Chen, Shin Chueh

AU - Chen, Chung Yuan

AU - Huang, Hsin Yang

AU - Chen, Jiunn Rong

AU - Lo, Hsiao Jung

AU - Yu, Neng Chun

AU - Liu, Wen Cheng

AU - Wu, Chun Han

AU - Chen, Deng Wang

AU - Shen, De Chung

AU - Chung, Wei Chen

PY - 2024/12

Y1 - 2024/12

N2 - Diabetic nephropathy is a critical complication of patients with type 1 diabetes, while epidemiological studies were scarce among Asian countries. We conducted a cross-sectional study to identify factors associated with diabetic nephropathy by questionnaires, using student’s t-test, chi-square test, and multivariable logistic regression. Among 898 participants, 16.7% had diabetic nephropathy. Compared with non-diabetic nephropathy patients, the patients with diabetic nephropathy had significantly higher percentage with onset age of type 1 diabetes between puberty and under 30 years old (female ≥ 12 or male ≥ 13 years old to 29 years old), longer diabetes duration, having family history of diabetes and diabetic nephropathy, accompanied with hypertension, hyperlipidemia, or coronary artery disease (CAD). Compared with patients with onset age before puberty, the odds of diabetic nephropathy occurrence increased to 1.61 times in patients with onset age between puberty and under 30 years old (p = 0.012) after adjusting diabetes duration. Age of diabetes onset between puberty and under 30 years old, diabetes duration, HbA1c, hospital admission within 3 years, diabetic retinopathy, hypertension, systolic blood pressure (SBP), triglyceride levels, and use of angiotensin converting enzyme inhibitor (ACEI) and/or angiotensin receptor blockers (ARB) were independent factors associated with diabetic nephropathy Screening for proteinuria is important in daily clinical practice and should be part of diabetes self-management education for patients with type 1 diabetes.

AB - Diabetic nephropathy is a critical complication of patients with type 1 diabetes, while epidemiological studies were scarce among Asian countries. We conducted a cross-sectional study to identify factors associated with diabetic nephropathy by questionnaires, using student’s t-test, chi-square test, and multivariable logistic regression. Among 898 participants, 16.7% had diabetic nephropathy. Compared with non-diabetic nephropathy patients, the patients with diabetic nephropathy had significantly higher percentage with onset age of type 1 diabetes between puberty and under 30 years old (female ≥ 12 or male ≥ 13 years old to 29 years old), longer diabetes duration, having family history of diabetes and diabetic nephropathy, accompanied with hypertension, hyperlipidemia, or coronary artery disease (CAD). Compared with patients with onset age before puberty, the odds of diabetic nephropathy occurrence increased to 1.61 times in patients with onset age between puberty and under 30 years old (p = 0.012) after adjusting diabetes duration. Age of diabetes onset between puberty and under 30 years old, diabetes duration, HbA1c, hospital admission within 3 years, diabetic retinopathy, hypertension, systolic blood pressure (SBP), triglyceride levels, and use of angiotensin converting enzyme inhibitor (ACEI) and/or angiotensin receptor blockers (ARB) were independent factors associated with diabetic nephropathy Screening for proteinuria is important in daily clinical practice and should be part of diabetes self-management education for patients with type 1 diabetes.

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