TY - JOUR
T1 - Age-dependent congener profiles of polychlorinated dibenzo-p-dioxins and dibenzofurans in the general population of Taiwan
AU - Hsu, Jing Fang
AU - Chang, Yu Chen
AU - Liao, Pao Chi
N1 - Funding Information:
This work was supported by Grants from the Bureau of Food and Drug Analysis, Department of Health, Executive Yuan, Taiwan, the National Science Council of Taiwan (NSC95-2113-M-006-006 and NSC96-2628-M-006-005) and the National Cheng Kung University Project of Promoting Academic Excellence & Developing World Class Research Centers from the Ministry of Education of Taiwan.
PY - 2010/9
Y1 - 2010/9
N2 - A congener profile of polychlorinated dibenzo-p-dioxin and dibenzofurans (PCDD/Fs) could provide valuable information for identifying possible sources of exposure to these compounds. The purpose of this study is to identify factors associated with PCDD/F congener profiles in the general population of Taiwan. Serum samples from 251 subjects of the general population in Taiwan were collected, and the levels of 17 2,3,7,8-chlorinated substituted PCDD/Fs were measured. The relationships between PCDD/F congener profiles and demographic parameters were evaluated using a multivariate analysis of variance method (MANOVA). Of the five demographic factors investigated, age was found to have the greatest impact on PCDD/F congener profiles. The PCDD/F congener pattern for the group I subjects (aged 18-29) was significantly different from those for the other three older age groups (p<0.001), and 12 congeners contributed to the effects (difference index: 71%). In addition, the group I subjects did not exhibit trends parallel to those of the other groups in the relationship between age and PCDD/F levels. Age was associated with PCDD/F levels and congener profiles in the general population of Taiwan and the young subjects (aged 18-29) was quite different from the other older subjects that could be influenced by the individual differences in pharmacokinetics and/or background exposure from dietary sources. We conclude that investigators must consider subjects' age and other underlying factors that could influence PCDD/F congener profiles in humans when identifying exposure sources.
AB - A congener profile of polychlorinated dibenzo-p-dioxin and dibenzofurans (PCDD/Fs) could provide valuable information for identifying possible sources of exposure to these compounds. The purpose of this study is to identify factors associated with PCDD/F congener profiles in the general population of Taiwan. Serum samples from 251 subjects of the general population in Taiwan were collected, and the levels of 17 2,3,7,8-chlorinated substituted PCDD/Fs were measured. The relationships between PCDD/F congener profiles and demographic parameters were evaluated using a multivariate analysis of variance method (MANOVA). Of the five demographic factors investigated, age was found to have the greatest impact on PCDD/F congener profiles. The PCDD/F congener pattern for the group I subjects (aged 18-29) was significantly different from those for the other three older age groups (p<0.001), and 12 congeners contributed to the effects (difference index: 71%). In addition, the group I subjects did not exhibit trends parallel to those of the other groups in the relationship between age and PCDD/F levels. Age was associated with PCDD/F levels and congener profiles in the general population of Taiwan and the young subjects (aged 18-29) was quite different from the other older subjects that could be influenced by the individual differences in pharmacokinetics and/or background exposure from dietary sources. We conclude that investigators must consider subjects' age and other underlying factors that could influence PCDD/F congener profiles in humans when identifying exposure sources.
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U2 - 10.1016/j.chemosphere.2010.07.044
DO - 10.1016/j.chemosphere.2010.07.044
M3 - Article
C2 - 20797765
AN - SCOPUS:77956886559
SN - 0045-6535
VL - 81
SP - 469
EP - 477
JO - Chemosphere
JF - Chemosphere
IS - 4
ER -