Airway infection predisposes to peristomal infection after percutaneous endoscopic gastrostomy with high concordance between sputum and wound isolates

Chiao-Hsiung Chuang, Kuei Hsiang Hung, Jen Ru Chen, Chiung-Yu Chen, Ai Wen Kao, Wei-Lun Chang, Jiunn Jong Wu, Bor-Shyang Sheu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Peristomal infection is common after percutaneous endoscopic gastrostomy. This study aims to evaluate the correlation between airway and peristomal infected pathogens. Methods: Before the procedure, sputum cultures were prospectively performed for the patients with airway symptoms. All the patients received prophylactic antibiotics. Once peristomal infection occurred, the wound cultures were obtained to analyze the antibiotic susceptibilities of the pathogens. The paired isolates, with concordance between sputum and wound cultures, were validated for their clone identity using pulsed-field gel electrophoresis. Results: One hundred twelve patients were enrolled, and 30 patients had peristomal infection. The 31 patients with airway pathogens had a 10-fold higher risk of peristomal infection than the other 81 without airway pathogens (95% CI, 3.85-26.4, p<0.001). Among patients collected with paired isolates from wound and sputum, 85% had concordant microorganism species. In the paired concordant isolates, 94% had indistinguishable antibiogram, and nearly 90% were clonally identical in pulsed-field gel electrophoresis. Conclusions: Patients with airway infection have an increased risk of peristomal infection after percutaneous endoscopic gastrostomy. Concerning the high concordance between infected wound and sputum isolates of such patients, the selection of appropriate prophylactic antibiotics could be individual to cover the microorganisms isolated from sputum.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalJournal of Gastrointestinal Surgery
Volume14
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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Gastrostomy
Sputum
Wounds and Injuries
Infection
Pulsed Field Gel Electrophoresis
Anti-Bacterial Agents
Microbial Sensitivity Tests
Wound Infection
Patient Selection
Clone Cells

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology

Cite this

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title = "Airway infection predisposes to peristomal infection after percutaneous endoscopic gastrostomy with high concordance between sputum and wound isolates",
abstract = "Background: Peristomal infection is common after percutaneous endoscopic gastrostomy. This study aims to evaluate the correlation between airway and peristomal infected pathogens. Methods: Before the procedure, sputum cultures were prospectively performed for the patients with airway symptoms. All the patients received prophylactic antibiotics. Once peristomal infection occurred, the wound cultures were obtained to analyze the antibiotic susceptibilities of the pathogens. The paired isolates, with concordance between sputum and wound cultures, were validated for their clone identity using pulsed-field gel electrophoresis. Results: One hundred twelve patients were enrolled, and 30 patients had peristomal infection. The 31 patients with airway pathogens had a 10-fold higher risk of peristomal infection than the other 81 without airway pathogens (95{\%} CI, 3.85-26.4, p<0.001). Among patients collected with paired isolates from wound and sputum, 85{\%} had concordant microorganism species. In the paired concordant isolates, 94{\%} had indistinguishable antibiogram, and nearly 90{\%} were clonally identical in pulsed-field gel electrophoresis. Conclusions: Patients with airway infection have an increased risk of peristomal infection after percutaneous endoscopic gastrostomy. Concerning the high concordance between infected wound and sputum isolates of such patients, the selection of appropriate prophylactic antibiotics could be individual to cover the microorganisms isolated from sputum.",
author = "Chiao-Hsiung Chuang and Hung, {Kuei Hsiang} and Chen, {Jen Ru} and Chiung-Yu Chen and Kao, {Ai Wen} and Wei-Lun Chang and Wu, {Jiunn Jong} and Bor-Shyang Sheu",
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T1 - Airway infection predisposes to peristomal infection after percutaneous endoscopic gastrostomy with high concordance between sputum and wound isolates

AU - Chuang, Chiao-Hsiung

AU - Hung, Kuei Hsiang

AU - Chen, Jen Ru

AU - Chen, Chiung-Yu

AU - Kao, Ai Wen

AU - Chang, Wei-Lun

AU - Wu, Jiunn Jong

AU - Sheu, Bor-Shyang

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Background: Peristomal infection is common after percutaneous endoscopic gastrostomy. This study aims to evaluate the correlation between airway and peristomal infected pathogens. Methods: Before the procedure, sputum cultures were prospectively performed for the patients with airway symptoms. All the patients received prophylactic antibiotics. Once peristomal infection occurred, the wound cultures were obtained to analyze the antibiotic susceptibilities of the pathogens. The paired isolates, with concordance between sputum and wound cultures, were validated for their clone identity using pulsed-field gel electrophoresis. Results: One hundred twelve patients were enrolled, and 30 patients had peristomal infection. The 31 patients with airway pathogens had a 10-fold higher risk of peristomal infection than the other 81 without airway pathogens (95% CI, 3.85-26.4, p<0.001). Among patients collected with paired isolates from wound and sputum, 85% had concordant microorganism species. In the paired concordant isolates, 94% had indistinguishable antibiogram, and nearly 90% were clonally identical in pulsed-field gel electrophoresis. Conclusions: Patients with airway infection have an increased risk of peristomal infection after percutaneous endoscopic gastrostomy. Concerning the high concordance between infected wound and sputum isolates of such patients, the selection of appropriate prophylactic antibiotics could be individual to cover the microorganisms isolated from sputum.

AB - Background: Peristomal infection is common after percutaneous endoscopic gastrostomy. This study aims to evaluate the correlation between airway and peristomal infected pathogens. Methods: Before the procedure, sputum cultures were prospectively performed for the patients with airway symptoms. All the patients received prophylactic antibiotics. Once peristomal infection occurred, the wound cultures were obtained to analyze the antibiotic susceptibilities of the pathogens. The paired isolates, with concordance between sputum and wound cultures, were validated for their clone identity using pulsed-field gel electrophoresis. Results: One hundred twelve patients were enrolled, and 30 patients had peristomal infection. The 31 patients with airway pathogens had a 10-fold higher risk of peristomal infection than the other 81 without airway pathogens (95% CI, 3.85-26.4, p<0.001). Among patients collected with paired isolates from wound and sputum, 85% had concordant microorganism species. In the paired concordant isolates, 94% had indistinguishable antibiogram, and nearly 90% were clonally identical in pulsed-field gel electrophoresis. Conclusions: Patients with airway infection have an increased risk of peristomal infection after percutaneous endoscopic gastrostomy. Concerning the high concordance between infected wound and sputum isolates of such patients, the selection of appropriate prophylactic antibiotics could be individual to cover the microorganisms isolated from sputum.

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