Alcohol drinking obliterates the inverse association between serum retinol and risk of head and neck cancer

Ken Chung Chen, Wei Ting Hsueh, Chun Yen Ou, Cheng Chih Huang, Wei Ting Lee, Sheen Yie Fang, Sen Tien Tsai, Jehn Shyun Huang, Tung Yiu Wong, Jiunn Liang Wu, Chia Jui Yen, Yuan Hua Wu, Forn Chia Lin, Ming Wei Yang, Jang Yang Chang, Hsiao Chen Liao, Shang Yin Wu, Jenn Ren Hsiao, Chen Lin Lin, Yi Hui WangYa Ling Weng, Han Chien Yang, Yu Shan Chen, Jeffrey S. Chang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This analysis evaluated the association between serum retinol levels and risk of head and neck cancer (HNC) and whether the association is modulated by the use of alcohol, betel quid, or cigarette. In addition, we also examined the association between HNC risk and 2 single nucleotide polymorphisms, TTR rs1667255 and RBP4 rs10882272, that have been associated with serum retinol levels. Unconditional logistic regression was performed to evaluate the association between serum retinol levels and HNC risk among 160 HNC cases and 198 controls. The associations between TTR rs1667255 and RBP4 rs10882272 and serum retinol levels or HNC risk were evaluated by linear regression and unconditional logistic regression, respectively, for 418 HNC cases and 497 controls. The results showed that HNC cases had a lower mean serum retinol level compared with controls (845.3mg/L vs 914.8mg/L, P=0.03). An inverse association between serum retinol levels and HNC risk occurred among never/occasional alcohol drinkers but not among regular drinkers. TTR rs1667255 was associated with serum retinol levels; however, neither TTR rs1667255 nor RBP4 rs10882272 was associated with HNC risk. In summary, this study showed an inverse association between serum retinol levels and HNC risk, specifically among never/occasional alcohol drinkers. More studies are needed to establish the underlying biologic mechanisms for the inverse association between serum retinol levels and HNC risk and the modulation of this relationship by alcohol drinking.

Original languageEnglish
Article numbere1064
JournalMedicine (United States)
Volume94
Issue number26
DOIs
Publication statusPublished - 2015 Jul 1

Fingerprint

Head and Neck Neoplasms
Vitamin A
Alcohol Drinking
Serum
Alcohols
Logistic Models
Tobacco Products
Single Nucleotide Polymorphism
Linear Models

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{e28954c028534e20b78ffd7aadf4f55d,
title = "Alcohol drinking obliterates the inverse association between serum retinol and risk of head and neck cancer",
abstract = "This analysis evaluated the association between serum retinol levels and risk of head and neck cancer (HNC) and whether the association is modulated by the use of alcohol, betel quid, or cigarette. In addition, we also examined the association between HNC risk and 2 single nucleotide polymorphisms, TTR rs1667255 and RBP4 rs10882272, that have been associated with serum retinol levels. Unconditional logistic regression was performed to evaluate the association between serum retinol levels and HNC risk among 160 HNC cases and 198 controls. The associations between TTR rs1667255 and RBP4 rs10882272 and serum retinol levels or HNC risk were evaluated by linear regression and unconditional logistic regression, respectively, for 418 HNC cases and 497 controls. The results showed that HNC cases had a lower mean serum retinol level compared with controls (845.3mg/L vs 914.8mg/L, P=0.03). An inverse association between serum retinol levels and HNC risk occurred among never/occasional alcohol drinkers but not among regular drinkers. TTR rs1667255 was associated with serum retinol levels; however, neither TTR rs1667255 nor RBP4 rs10882272 was associated with HNC risk. In summary, this study showed an inverse association between serum retinol levels and HNC risk, specifically among never/occasional alcohol drinkers. More studies are needed to establish the underlying biologic mechanisms for the inverse association between serum retinol levels and HNC risk and the modulation of this relationship by alcohol drinking.",
author = "Chen, {Ken Chung} and Hsueh, {Wei Ting} and Ou, {Chun Yen} and Huang, {Cheng Chih} and Lee, {Wei Ting} and Fang, {Sheen Yie} and Tsai, {Sen Tien} and Huang, {Jehn Shyun} and Wong, {Tung Yiu} and Wu, {Jiunn Liang} and Yen, {Chia Jui} and Wu, {Yuan Hua} and Lin, {Forn Chia} and Yang, {Ming Wei} and Chang, {Jang Yang} and Liao, {Hsiao Chen} and Wu, {Shang Yin} and Hsiao, {Jenn Ren} and Lin, {Chen Lin} and Wang, {Yi Hui} and Weng, {Ya Ling} and Yang, {Han Chien} and Chen, {Yu Shan} and Chang, {Jeffrey S.}",
year = "2015",
month = "7",
day = "1",
doi = "10.1097/MD.0000000000001064",
language = "English",
volume = "94",
journal = "Medicine (United States)",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "26",

}

TY - JOUR

T1 - Alcohol drinking obliterates the inverse association between serum retinol and risk of head and neck cancer

AU - Chen, Ken Chung

AU - Hsueh, Wei Ting

AU - Ou, Chun Yen

AU - Huang, Cheng Chih

AU - Lee, Wei Ting

AU - Fang, Sheen Yie

AU - Tsai, Sen Tien

AU - Huang, Jehn Shyun

AU - Wong, Tung Yiu

AU - Wu, Jiunn Liang

AU - Yen, Chia Jui

AU - Wu, Yuan Hua

AU - Lin, Forn Chia

AU - Yang, Ming Wei

AU - Chang, Jang Yang

AU - Liao, Hsiao Chen

AU - Wu, Shang Yin

AU - Hsiao, Jenn Ren

AU - Lin, Chen Lin

AU - Wang, Yi Hui

AU - Weng, Ya Ling

AU - Yang, Han Chien

AU - Chen, Yu Shan

AU - Chang, Jeffrey S.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - This analysis evaluated the association between serum retinol levels and risk of head and neck cancer (HNC) and whether the association is modulated by the use of alcohol, betel quid, or cigarette. In addition, we also examined the association between HNC risk and 2 single nucleotide polymorphisms, TTR rs1667255 and RBP4 rs10882272, that have been associated with serum retinol levels. Unconditional logistic regression was performed to evaluate the association between serum retinol levels and HNC risk among 160 HNC cases and 198 controls. The associations between TTR rs1667255 and RBP4 rs10882272 and serum retinol levels or HNC risk were evaluated by linear regression and unconditional logistic regression, respectively, for 418 HNC cases and 497 controls. The results showed that HNC cases had a lower mean serum retinol level compared with controls (845.3mg/L vs 914.8mg/L, P=0.03). An inverse association between serum retinol levels and HNC risk occurred among never/occasional alcohol drinkers but not among regular drinkers. TTR rs1667255 was associated with serum retinol levels; however, neither TTR rs1667255 nor RBP4 rs10882272 was associated with HNC risk. In summary, this study showed an inverse association between serum retinol levels and HNC risk, specifically among never/occasional alcohol drinkers. More studies are needed to establish the underlying biologic mechanisms for the inverse association between serum retinol levels and HNC risk and the modulation of this relationship by alcohol drinking.

AB - This analysis evaluated the association between serum retinol levels and risk of head and neck cancer (HNC) and whether the association is modulated by the use of alcohol, betel quid, or cigarette. In addition, we also examined the association between HNC risk and 2 single nucleotide polymorphisms, TTR rs1667255 and RBP4 rs10882272, that have been associated with serum retinol levels. Unconditional logistic regression was performed to evaluate the association between serum retinol levels and HNC risk among 160 HNC cases and 198 controls. The associations between TTR rs1667255 and RBP4 rs10882272 and serum retinol levels or HNC risk were evaluated by linear regression and unconditional logistic regression, respectively, for 418 HNC cases and 497 controls. The results showed that HNC cases had a lower mean serum retinol level compared with controls (845.3mg/L vs 914.8mg/L, P=0.03). An inverse association between serum retinol levels and HNC risk occurred among never/occasional alcohol drinkers but not among regular drinkers. TTR rs1667255 was associated with serum retinol levels; however, neither TTR rs1667255 nor RBP4 rs10882272 was associated with HNC risk. In summary, this study showed an inverse association between serum retinol levels and HNC risk, specifically among never/occasional alcohol drinkers. More studies are needed to establish the underlying biologic mechanisms for the inverse association between serum retinol levels and HNC risk and the modulation of this relationship by alcohol drinking.

UR - http://www.scopus.com/inward/record.url?scp=84942511877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942511877&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000001064

DO - 10.1097/MD.0000000000001064

M3 - Article

C2 - 26131827

AN - SCOPUS:84942511877

VL - 94

JO - Medicine (United States)

JF - Medicine (United States)

SN - 0025-7974

IS - 26

M1 - e1064

ER -