ALDH2 gene: ITS effects on the neuropsychological functions in patients with opioid use disorder undergoing methadone maintenance treatment

Po Wei Lee, Tzu Yun Wang, Yun Hsuan Chang, Sheng Yu Lee, Shiou Lan Chen, Ze Cheng Wang, Po See Chen, Chun Hsien Chu, San Yuan Huang, Nian Sheng Tzeng, I. Hui Lee, Kao Chin Chen, Yen Kuang Yang, Jau Shyong Hong, Ru Band Lu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Objective: Patients with opioid use disorder (OUD) have impaired attention, inhibition control, and memory function. The aldehyde dehydrogenase 2 (ALDH2) gene has been associated with OUD and ALDH2 gene polymorphisms may affect aldehyde metabolism and cognitive function in other substance use disorder. Therefore, we aimed to investigate whether ALDH2 genotypes have significant effects on neuropsychological functions in OUD patients undergoing methadone maintenance therapy (MMT). Methods: OUD patients undergoing MMT were investigated and followed-up for 12 weeks. ALDH2 gene polymorphisms were genotyped. Connors' Continuous Performance Test (CPT) and the Wechsler Memory Scale-Revised (WMS-R) were administered at baseline and after 12 weeks of MMT. Multivariate linear regressions and generalized estimating equations (GEEs) were used to examine the correlation between the ALDH2 genotypes and performance on the CPTs and WMS-R. Results: We enrolled 86 patients at baseline; 61 patients completed the end-of-study assessments. The GEE analysis showed that, after the 12 weeks of MMT, OUD patients with the ALDH2 *1/*2+*2/*2 (ALDH2 inactive) genotypes had significantly higher commission error T-scores (p = 0.03), significantly lower hit reaction time T-scores (p = 0.04), and significantly lower WMS-R visual memory index scores (p = 0.03) than did patients with the ALDH2 1*/*1 (ALDH2 active) genotype. Conclusion: OUD patients with the ALDH2 inactive genotypes performed worse in cognitive domains of attention, impulse control, and memory than did those with the ALDH2 active genotype. We conclude that the ALDH2 gene is important in OUD and is associated with neuropsychological performance after MMT.

Original languageEnglish
Pages (from-to)136-144
Number of pages9
JournalClinical Psychopharmacology and Neuroscience
Issue number1
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Pharmacology (medical)


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