Alkyl chain-grafted poly(l -lysine) vesicles with tunable molecular assembly and membrane permeability

Bo Yu Chen, Yi Fong Huang, Yun Chiao Huang, Tain Ching Wen, Jeng Shiung Jan

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


The preparation of alkyl chain-grafted poly(l-lysine) (PLL) vesicles with tunable molecular assembly in aqueous solution and the evaluation of their membrane permeability by drug release experiments have been investigated. Upon grafting long alkyl chains, polypeptides confined in the assembled nanostructures adopted ordered conformations such as α-helices or β-sheets/turns, leading to the dense packing of membranes and, consequently, the decreases in vesicular size and membrane permeability. The vesicles can also be cross-linked by genipin to form stable structures with tunable membrane permeability. Additionally, these vesicles exhibited noticeable pH-sensitive behavior, depending on the grafted alkyl chain and cross-linking.

Original languageEnglish
Pages (from-to)220-223
Number of pages4
JournalACS Macro Letters
Issue number3
Publication statusPublished - 2014 Mar 18

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry


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