Allergic colitis in infants related to cow's milk: Clinical characteristics, pathologic changes, and immunologic findings

Man Chun Yu, Chia Lun Tsai, Yao Jong Yang, Sing San Yang, Li Hui Wang, Chung Ta Lee, Ren Long Jan, Jiu Yao Wang

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Background: Allergic colitis (AC) is an inflammatory condition characterized by eosinophils infiltrating the colonic wall. It can be a benign and/or severe illness among gastrointestinal diseases in infants. Methods: We report five infants who, since January 2009, in whom AC under fibrotic endoscopic examinations has been diagnosed. The criterion for histopathologic diagnosis of AC in this study was five or more eosinophils per high-power field. Patients' clinical symptoms, pathologic findings, and immunologic studies, such as specific antibodies against component of cow's milk protein, were compared with those of allergic children without AC and those of nonatopic control children. Results: Histopathologic examinations of biopsy specimens revealed acute inflammation with characteristic eosinophilic infiltration of lamina propria (5-15 eosinophils per high-power field) in all five patients. They all had strongly positive skin prick tests against milk protein, which were not correlated with in vitro allergen-specific immunoglobulin (Ig) E levels. In contrast, there were significantly higher levels of IgE antibodies, and lower specific IgG4 and IgA levels to components and whole milk proteins in AC, as compared to control children without AC. Conclusion: Endoscopic biopsy specimens of intestine confirm the diagnosis of AC. However, allergen skin prick test and IgE antibody to milk protein components also provide helpful diagnostic tools for this rare disease in children.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalPediatrics and Neonatology
Issue number1
Publication statusPublished - 2013 Feb

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Allergic colitis in infants related to cow's milk: Clinical characteristics, pathologic changes, and immunologic findings'. Together they form a unique fingerprint.

Cite this