Alloantibody and xenoantibody cross-reactivity in transplantation

D. K.C. Cooper, Yau-Lin Tseng, S. L. Saidman

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

The recent availability of pigs homozygous for α 1,3-galactosyltransferase gene knockout, and improved immunosuppressive regimens that prevent an elicited antibody response, are expected to contribute to significantly increased survival of pig organs transplanted into primates, bringing clinical trials of xenotransplantation closer. Patients highly sensitized to human leukocyte antigens, who may be precluded from obtaining a human donor organ, would be one group that might benefit from xenotransplantation. However, there have been few studies on whether there is cross-reactivity of anti-human leukocyte antigen antibodies with pig antigens. What data there are suggest that such cross-reactivity exists and that this may be detrimental to the outcome after transplantation of a pig organ. Neither is it known whether sensitization after a pig xenograft would preclude subsequent allotransplantation, although the data available suggest that this will not be the case. Further investigation on allo- and xenoantibody cross-reactivity is required.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalTransplantation
Volume77
Issue number1
DOIs
Publication statusPublished - 2004 Jan 15

Fingerprint

Heterophile Antibodies
Isoantibodies
Swine
Transplantation
Heterologous Transplantation
HLA Antigens
Galactosyltransferases
Tissue Survival
Gene Knockout Techniques
Immunosuppressive Agents
Heterografts
Primates
Antibody Formation
Tissue Donors
Clinical Trials
Antigens
Antibodies

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Cooper, D. K.C. ; Tseng, Yau-Lin ; Saidman, S. L. / Alloantibody and xenoantibody cross-reactivity in transplantation. In: Transplantation. 2004 ; Vol. 77, No. 1. pp. 1-5.
@article{467314887fb4489eb210a8017c1d2f65,
title = "Alloantibody and xenoantibody cross-reactivity in transplantation",
abstract = "The recent availability of pigs homozygous for α 1,3-galactosyltransferase gene knockout, and improved immunosuppressive regimens that prevent an elicited antibody response, are expected to contribute to significantly increased survival of pig organs transplanted into primates, bringing clinical trials of xenotransplantation closer. Patients highly sensitized to human leukocyte antigens, who may be precluded from obtaining a human donor organ, would be one group that might benefit from xenotransplantation. However, there have been few studies on whether there is cross-reactivity of anti-human leukocyte antigen antibodies with pig antigens. What data there are suggest that such cross-reactivity exists and that this may be detrimental to the outcome after transplantation of a pig organ. Neither is it known whether sensitization after a pig xenograft would preclude subsequent allotransplantation, although the data available suggest that this will not be the case. Further investigation on allo- and xenoantibody cross-reactivity is required.",
author = "Cooper, {D. K.C.} and Yau-Lin Tseng and Saidman, {S. L.}",
year = "2004",
month = "1",
day = "15",
doi = "10.1097/01.TP.0000105116.74032.63",
language = "English",
volume = "77",
pages = "1--5",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

Alloantibody and xenoantibody cross-reactivity in transplantation. / Cooper, D. K.C.; Tseng, Yau-Lin; Saidman, S. L.

In: Transplantation, Vol. 77, No. 1, 15.01.2004, p. 1-5.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Alloantibody and xenoantibody cross-reactivity in transplantation

AU - Cooper, D. K.C.

AU - Tseng, Yau-Lin

AU - Saidman, S. L.

PY - 2004/1/15

Y1 - 2004/1/15

N2 - The recent availability of pigs homozygous for α 1,3-galactosyltransferase gene knockout, and improved immunosuppressive regimens that prevent an elicited antibody response, are expected to contribute to significantly increased survival of pig organs transplanted into primates, bringing clinical trials of xenotransplantation closer. Patients highly sensitized to human leukocyte antigens, who may be precluded from obtaining a human donor organ, would be one group that might benefit from xenotransplantation. However, there have been few studies on whether there is cross-reactivity of anti-human leukocyte antigen antibodies with pig antigens. What data there are suggest that such cross-reactivity exists and that this may be detrimental to the outcome after transplantation of a pig organ. Neither is it known whether sensitization after a pig xenograft would preclude subsequent allotransplantation, although the data available suggest that this will not be the case. Further investigation on allo- and xenoantibody cross-reactivity is required.

AB - The recent availability of pigs homozygous for α 1,3-galactosyltransferase gene knockout, and improved immunosuppressive regimens that prevent an elicited antibody response, are expected to contribute to significantly increased survival of pig organs transplanted into primates, bringing clinical trials of xenotransplantation closer. Patients highly sensitized to human leukocyte antigens, who may be precluded from obtaining a human donor organ, would be one group that might benefit from xenotransplantation. However, there have been few studies on whether there is cross-reactivity of anti-human leukocyte antigen antibodies with pig antigens. What data there are suggest that such cross-reactivity exists and that this may be detrimental to the outcome after transplantation of a pig organ. Neither is it known whether sensitization after a pig xenograft would preclude subsequent allotransplantation, although the data available suggest that this will not be the case. Further investigation on allo- and xenoantibody cross-reactivity is required.

UR - http://www.scopus.com/inward/record.url?scp=1642443483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642443483&partnerID=8YFLogxK

U2 - 10.1097/01.TP.0000105116.74032.63

DO - 10.1097/01.TP.0000105116.74032.63

M3 - Review article

C2 - 14724427

AN - SCOPUS:1642443483

VL - 77

SP - 1

EP - 5

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 1

ER -