Alopecia universalis associated with a mutation in the human hairless gene

Wasim Ahmad; Muhammad Faiyaz Ul Haque; Valeria Brancolini; Hui C. Tsou; Sayed Ul Haque; Hamut Lam; Vincent M. Aita; Jason Owen; Michelle DeBlaquiere; Jorge Frank; Peter B. Cserhalmi-Friedman; Andrew Leask; John A. McGrath; Monica Peacocke; Mahmud Ahmad; Jurg Ott; Angela M. Christiano

doi:10.1126/science.279.5351.720

Alopecia universalis associated with a mutation in the human hairless gene

Wasim Ahmad, Muhammad Faiyaz Ul Haque, Valeria Brancolini, Hui C. Tsou, Sayed Ul Haque, Hamut Lam, Vincent M. Aita, Jason Owen, Michelle DeBlaquiere, Jorge Frank, Peter B. Cserhalmi-Friedman, Andrew Leask, John A. McGrath, Monica Peacocke, Mahmud Ahmad, Jurg Ott, Angela M. Christiano

Department of Dermatology

Research output: Contribution to journal › Article › peer-review

382 Citations (Scopus)

Abstract

There are several forms of hereditary human hair loss, known collectively as alopecias, the molecular bases of which are entirely unknown. A kindred with a rare, recessively inherited type of alopecia universalis was used to search for a locus by homozygosity mapping, and linkage was established in a 6-centimorgan interval on chromosome 8p12 (the logarithm of the odds favoring linkage score was 6.19). The human homolog of a murine gene, hairless, was localized in this interval by radiation hybrid mapping, and a missense mutation was found in affected individuals. Human hairless encodes a putative single zinc finger transcription factor protein with restricted expression in the brain and skin.

Original language	English
Pages (from-to)	720-724
Number of pages	5
Journal	Science
Volume	279
Issue number	5351
DOIs	https://doi.org/10.1126/science.279.5351.720
Publication status	Published - 1998 Jan 30

All Science Journal Classification (ASJC) codes

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Ahmad, W., Ul Haque, M. F., Brancolini, V., Tsou, H. C., Ul Haque, S., Lam, H., Aita, V. M., Owen, J., DeBlaquiere, M., Frank, J., Cserhalmi-Friedman, P. B., Leask, A., McGrath, J. A., Peacocke, M., Ahmad, M., Ott, J., & Christiano, A. M. (1998). Alopecia universalis associated with a mutation in the human hairless gene. Science, 279(5351), 720-724. https://doi.org/10.1126/science.279.5351.720

@article{23c4545102514a27bc9bff5320a9a40f,

title = "Alopecia universalis associated with a mutation in the human hairless gene",

abstract = "There are several forms of hereditary human hair loss, known collectively as alopecias, the molecular bases of which are entirely unknown. A kindred with a rare, recessively inherited type of alopecia universalis was used to search for a locus by homozygosity mapping, and linkage was established in a 6-centimorgan interval on chromosome 8p12 (the logarithm of the odds favoring linkage score was 6.19). The human homolog of a murine gene, hairless, was localized in this interval by radiation hybrid mapping, and a missense mutation was found in affected individuals. Human hairless encodes a putative single zinc finger transcription factor protein with restricted expression in the brain and skin.",

author = "Wasim Ahmad and {Ul Haque}, {Muhammad Faiyaz} and Valeria Brancolini and Tsou, {Hui C.} and {Ul Haque}, Sayed and Hamut Lam and Aita, {Vincent M.} and Jason Owen and Michelle DeBlaquiere and Jorge Frank and Cserhalmi-Friedman, {Peter B.} and Andrew Leask and McGrath, {John A.} and Monica Peacocke and Mahmud Ahmad and Jurg Ott and Christiano, {Angela M.}",

year = "1998",

month = jan,

day = "30",

doi = "10.1126/science.279.5351.720",

language = "English",

volume = "279",

pages = "720--724",

journal = "Science",

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Ahmad, W, Ul Haque, MF, Brancolini, V, Tsou, HC, Ul Haque, S, Lam, H, Aita, VM, Owen, J, DeBlaquiere, M, Frank, J, Cserhalmi-Friedman, PB, Leask, A, McGrath, JA, Peacocke, M, Ahmad, M, Ott, J & Christiano, AM 1998, 'Alopecia universalis associated with a mutation in the human hairless gene', Science, vol. 279, no. 5351, pp. 720-724. https://doi.org/10.1126/science.279.5351.720

TY - JOUR

T1 - Alopecia universalis associated with a mutation in the human hairless gene

AU - Ahmad, Wasim

AU - Ul Haque, Muhammad Faiyaz

AU - Brancolini, Valeria

AU - Tsou, Hui C.

AU - Ul Haque, Sayed

AU - Lam, Hamut

AU - Aita, Vincent M.

AU - Owen, Jason

AU - DeBlaquiere, Michelle

AU - Frank, Jorge

AU - Cserhalmi-Friedman, Peter B.

AU - Leask, Andrew

AU - McGrath, John A.

AU - Peacocke, Monica

AU - Ahmad, Mahmud

AU - Ott, Jurg

AU - Christiano, Angela M.

PY - 1998/1/30

Y1 - 1998/1/30

N2 - There are several forms of hereditary human hair loss, known collectively as alopecias, the molecular bases of which are entirely unknown. A kindred with a rare, recessively inherited type of alopecia universalis was used to search for a locus by homozygosity mapping, and linkage was established in a 6-centimorgan interval on chromosome 8p12 (the logarithm of the odds favoring linkage score was 6.19). The human homolog of a murine gene, hairless, was localized in this interval by radiation hybrid mapping, and a missense mutation was found in affected individuals. Human hairless encodes a putative single zinc finger transcription factor protein with restricted expression in the brain and skin.

AB - There are several forms of hereditary human hair loss, known collectively as alopecias, the molecular bases of which are entirely unknown. A kindred with a rare, recessively inherited type of alopecia universalis was used to search for a locus by homozygosity mapping, and linkage was established in a 6-centimorgan interval on chromosome 8p12 (the logarithm of the odds favoring linkage score was 6.19). The human homolog of a murine gene, hairless, was localized in this interval by radiation hybrid mapping, and a missense mutation was found in affected individuals. Human hairless encodes a putative single zinc finger transcription factor protein with restricted expression in the brain and skin.

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Alopecia universalis associated with a mutation in the human hairless gene

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