Alpha-Actinin 4 and Tumorigenesis of Breast Cancer

Kuo Sheng Hsu, Hung-Ying Kao

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Citations (Scopus)

Abstract

Alpha-actinins (ACTNs) were originally identified as cytoskeletal proteins which cross-link filamentous actin to establish cytoskeletal architect that protects cells from mechanical stress and controls cell movement. Notably, unlike other ACTNs, alpha-actinin 4 (ACTN4) displays unique characteristics in signaling transduction, nuclear translocation, and gene expression regulation. Initial reports indicated that ACTN4 is part of the breast cancer cell motile apparatus and is highly expressed in the nucleus. These results imply that ACTN4 plays a role in breast cancer tumorigenesis. While several observations in breast cancer and other cancers support this hypothesis, little direct evidence links the tumorigenic phenotype with ACTN4-mediated pathological mechanisms. Recently, several studies have demonstrated that in addition to its role in coordinating cytoskeleton, ACTN4 interacts with signaling mediators, chromatin remodeling factors, and transcription factors including nuclear receptors. Thus, ACTN4 functions as a versatile promoter for breast cancer tumorigenesis and appears to be an ideal drug target for future therapeutic development.

Original languageEnglish
Title of host publicationVitamins and Hormones
PublisherAcademic Press Inc.
Pages323-351
Number of pages29
DOIs
Publication statusPublished - 2013 Jan 1

Publication series

NameVitamins and Hormones
Volume93
ISSN (Print)0083-6729

Fingerprint

Actinin
Carcinogenesis
Breast Neoplasms
Mechanical Stress
Chromatin Assembly and Disassembly
Cytoskeletal Proteins
Gene Expression Regulation
Cytoplasmic and Nuclear Receptors
Cytoskeleton
Cell Movement
Actins
Transcription Factors
Phenotype

All Science Journal Classification (ASJC) codes

  • Physiology
  • Endocrinology

Cite this

Hsu, K. S., & Kao, H-Y. (2013). Alpha-Actinin 4 and Tumorigenesis of Breast Cancer. In Vitamins and Hormones (pp. 323-351). (Vitamins and Hormones; Vol. 93). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-416673-8.00005-8
Hsu, Kuo Sheng ; Kao, Hung-Ying. / Alpha-Actinin 4 and Tumorigenesis of Breast Cancer. Vitamins and Hormones. Academic Press Inc., 2013. pp. 323-351 (Vitamins and Hormones).
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Hsu, KS & Kao, H-Y 2013, Alpha-Actinin 4 and Tumorigenesis of Breast Cancer. in Vitamins and Hormones. Vitamins and Hormones, vol. 93, Academic Press Inc., pp. 323-351. https://doi.org/10.1016/B978-0-12-416673-8.00005-8

Alpha-Actinin 4 and Tumorigenesis of Breast Cancer. / Hsu, Kuo Sheng; Kao, Hung-Ying.

Vitamins and Hormones. Academic Press Inc., 2013. p. 323-351 (Vitamins and Hormones; Vol. 93).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Hsu KS, Kao H-Y. Alpha-Actinin 4 and Tumorigenesis of Breast Cancer. In Vitamins and Hormones. Academic Press Inc. 2013. p. 323-351. (Vitamins and Hormones). https://doi.org/10.1016/B978-0-12-416673-8.00005-8