Alpha-Actinin 4 and Tumorigenesis of Breast Cancer

Kuo Sheng Hsu, Hung Ying Kao

Research output: Chapter in Book/Report/Conference proceedingChapter

32 Citations (Scopus)

Abstract

Alpha-actinins (ACTNs) were originally identified as cytoskeletal proteins which cross-link filamentous actin to establish cytoskeletal architect that protects cells from mechanical stress and controls cell movement. Notably, unlike other ACTNs, alpha-actinin 4 (ACTN4) displays unique characteristics in signaling transduction, nuclear translocation, and gene expression regulation. Initial reports indicated that ACTN4 is part of the breast cancer cell motile apparatus and is highly expressed in the nucleus. These results imply that ACTN4 plays a role in breast cancer tumorigenesis. While several observations in breast cancer and other cancers support this hypothesis, little direct evidence links the tumorigenic phenotype with ACTN4-mediated pathological mechanisms. Recently, several studies have demonstrated that in addition to its role in coordinating cytoskeleton, ACTN4 interacts with signaling mediators, chromatin remodeling factors, and transcription factors including nuclear receptors. Thus, ACTN4 functions as a versatile promoter for breast cancer tumorigenesis and appears to be an ideal drug target for future therapeutic development.

Original languageEnglish
Title of host publicationVitamins and Hormones
PublisherAcademic Press Inc.
Pages323-351
Number of pages29
DOIs
Publication statusPublished - 2013

Publication series

NameVitamins and Hormones
Volume93
ISSN (Print)0083-6729

All Science Journal Classification (ASJC) codes

  • Physiology
  • Endocrinology

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