Altered auditory p300 performance in parents with attention deficit hyperactivity disorder offspring

Mei Hung Chi; Ching Lin Chu; I. Hui Lee; Yi Ting Hsieh; Ko Chin Chen; Po See Chen; Yen Kuang Yang

doi:10.9758/cpn.2019.17.4.509

Altered auditory p300 performance in parents with attention deficit hyperactivity disorder offspring

Mei Hung Chi, Ching Lin Chu, I. Hui Lee, Yi Ting Hsieh, Ko Chin Chen, Po See Chen, Yen Kuang Yang

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Objective: Altered event-related potential (ERP) performances have been noted in attention deficit hyperactivity disorder (ADHD) patients and reflect neurocognitive dysfunction. Whether these ERP alterations and correlated dysfunctions exist in healthy parents with ADHD offspring is worth exploring. Methods: Thirteen healthy parents with ADHD offspring and thirteen healthy controls matched for age, sex and years of education were recruited. The auditory oddball paradigm was used to evaluate the P300 wave complex of the ERP, and the Wechsler Adult Intelligence Scale-Revised, Wisconsin Card Sorting Test, and continuous performance test were used to measure neurocognitive performance. Results: Healthy parents with ADHD offspring had significantly longer auditory P300 latency at Fz than control group. However, no significant differences were found in cognitive performance. Conclusion: The presence of a subtle alteration in electro-neurophysiological activity without explicit neurocognitive dysfunction suggests potential candidate of biological marker for parents with ADHD offspring.

Original language	English
Pages (from-to)	509-516
Number of pages	8
Journal	Clinical Psychopharmacology and Neuroscience
Volume	17
Issue number	4
DOIs	https://doi.org/10.9758/cpn.2019.17.4.509
Publication status	Published - 2019

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Behavioral Neuroscience
Pharmacology (medical)

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10.9758/cpn.2019.17.4.509

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title = "Altered auditory p300 performance in parents with attention deficit hyperactivity disorder offspring",

abstract = "Objective: Altered event-related potential (ERP) performances have been noted in attention deficit hyperactivity disorder (ADHD) patients and reflect neurocognitive dysfunction. Whether these ERP alterations and correlated dysfunctions exist in healthy parents with ADHD offspring is worth exploring. Methods: Thirteen healthy parents with ADHD offspring and thirteen healthy controls matched for age, sex and years of education were recruited. The auditory oddball paradigm was used to evaluate the P300 wave complex of the ERP, and the Wechsler Adult Intelligence Scale-Revised, Wisconsin Card Sorting Test, and continuous performance test were used to measure neurocognitive performance. Results: Healthy parents with ADHD offspring had significantly longer auditory P300 latency at Fz than control group. However, no significant differences were found in cognitive performance. Conclusion: The presence of a subtle alteration in electro-neurophysiological activity without explicit neurocognitive dysfunction suggests potential candidate of biological marker for parents with ADHD offspring.",

author = "Chi, {Mei Hung} and Chu, {Ching Lin} and Lee, {I. Hui} and Hsieh, {Yi Ting} and Chen, {Ko Chin} and Chen, {Po See} and Yang, {Yen Kuang}",

note = "Funding Information: This study was funded by the National Science Council of Taiwan (NSC 102-2420-H-006-007-MY2), the Ministry of Science and Technology, R.O.C. (MOST 104-2314-B-006-053-MY2), and National Cheng Kung University Hospital (NCKUH-10104019 and NCKUH-10405033). The funding institutions of this study had no further role in the study design, the collection, analysis, and interpretation of data, the writing of this paper, or the decision to submit it for publication. The authors are indebted to Ms. Tsai Hua Chang from National Cheng Kung University Hospital. Publisher Copyright: {\textcopyright} 2019, Korean College of Neuropsychopharmacology.",

year = "2019",

doi = "10.9758/cpn.2019.17.4.509",

language = "English",

volume = "17",

pages = "509--516",

journal = "Clinical Psychopharmacology and Neuroscience",

issn = "1738-1088",

publisher = "Korean College of Neuropsychopharmacology",

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T1 - Altered auditory p300 performance in parents with attention deficit hyperactivity disorder offspring

AU - Chi, Mei Hung

AU - Chu, Ching Lin

AU - Lee, I. Hui

AU - Hsieh, Yi Ting

AU - Chen, Ko Chin

AU - Chen, Po See

AU - Yang, Yen Kuang

N1 - Funding Information: This study was funded by the National Science Council of Taiwan (NSC 102-2420-H-006-007-MY2), the Ministry of Science and Technology, R.O.C. (MOST 104-2314-B-006-053-MY2), and National Cheng Kung University Hospital (NCKUH-10104019 and NCKUH-10405033). The funding institutions of this study had no further role in the study design, the collection, analysis, and interpretation of data, the writing of this paper, or the decision to submit it for publication. The authors are indebted to Ms. Tsai Hua Chang from National Cheng Kung University Hospital. Publisher Copyright: © 2019, Korean College of Neuropsychopharmacology.

PY - 2019

Y1 - 2019

N2 - Objective: Altered event-related potential (ERP) performances have been noted in attention deficit hyperactivity disorder (ADHD) patients and reflect neurocognitive dysfunction. Whether these ERP alterations and correlated dysfunctions exist in healthy parents with ADHD offspring is worth exploring. Methods: Thirteen healthy parents with ADHD offspring and thirteen healthy controls matched for age, sex and years of education were recruited. The auditory oddball paradigm was used to evaluate the P300 wave complex of the ERP, and the Wechsler Adult Intelligence Scale-Revised, Wisconsin Card Sorting Test, and continuous performance test were used to measure neurocognitive performance. Results: Healthy parents with ADHD offspring had significantly longer auditory P300 latency at Fz than control group. However, no significant differences were found in cognitive performance. Conclusion: The presence of a subtle alteration in electro-neurophysiological activity without explicit neurocognitive dysfunction suggests potential candidate of biological marker for parents with ADHD offspring.

AB - Objective: Altered event-related potential (ERP) performances have been noted in attention deficit hyperactivity disorder (ADHD) patients and reflect neurocognitive dysfunction. Whether these ERP alterations and correlated dysfunctions exist in healthy parents with ADHD offspring is worth exploring. Methods: Thirteen healthy parents with ADHD offspring and thirteen healthy controls matched for age, sex and years of education were recruited. The auditory oddball paradigm was used to evaluate the P300 wave complex of the ERP, and the Wechsler Adult Intelligence Scale-Revised, Wisconsin Card Sorting Test, and continuous performance test were used to measure neurocognitive performance. Results: Healthy parents with ADHD offspring had significantly longer auditory P300 latency at Fz than control group. However, no significant differences were found in cognitive performance. Conclusion: The presence of a subtle alteration in electro-neurophysiological activity without explicit neurocognitive dysfunction suggests potential candidate of biological marker for parents with ADHD offspring.

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Altered auditory p300 performance in parents with attention deficit hyperactivity disorder offspring

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