Abstract
An alternative route from (1R)-(+)-camphor to chiral N-substituted camphor-derived β-amino alcohol (4b-e) consists of four steps with a total yield of 28%. N-Alkylation of camphor-derived β-amino alcohol (4a) involves condensation and hydride reduction in one pot without isolation of intermediates. Condensation of 4a with aldehydes or ketones generates a mixture of 1,3-oxazolidines (6) and imino-alcohols (7), which are reduced to 4b-e by NaBH4.
| Original language | English |
|---|---|
| Pages (from-to) | 235-238 |
| Number of pages | 4 |
| Journal | Chirality |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2007 Mar 1 |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Organic Chemistry
- Drug Discovery
- Pharmacology
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Cheng, G. I., Shei, C. T., & Sung, K-S. (2007). Alternative synthetic route to chiral N-substituted camphor-derived β-amino alcohols. Chirality, 19(3), 235-238. https://doi.org/10.1002/chir.20373