An alternative route from (1R)-(+)-camphor to chiral N-substituted camphor-derived β-amino alcohol (4b-e) consists of four steps with a total yield of 28%. N-Alkylation of camphor-derived β-amino alcohol (4a) involves condensation and hydride reduction in one pot without isolation of intermediates. Condensation of 4a with aldehydes or ketones generates a mixture of 1,3-oxazolidines (6) and imino-alcohols (7), which are reduced to 4b-e by NaBH4.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Organic Chemistry
- Drug Discovery