Abstract
An alternative route from (1R)-(+)-camphor to chiral N-substituted camphor-derived β-amino alcohol (4b-e) consists of four steps with a total yield of 28%. N-Alkylation of camphor-derived β-amino alcohol (4a) involves condensation and hydride reduction in one pot without isolation of intermediates. Condensation of 4a with aldehydes or ketones generates a mixture of 1,3-oxazolidines (6) and imino-alcohols (7), which are reduced to 4b-e by NaBH4.
Original language | English |
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Pages (from-to) | 235-238 |
Number of pages | 4 |
Journal | Chirality |
Volume | 19 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2007 Mar 1 |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Organic Chemistry
- Drug Discovery
- Pharmacology