Amphiregulin as a tumor promoter for oral squamous cell carcinoma: Involvement of cyclooxygenase 2

Sen Tien Tsai, Kai Ying Yang, Ying Tai Jin, Yen Chun Lin, Mei Tzu Chang, Li Wha Wu

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Amphiregulin (AR), an epidermal growth factor (EGF)-like molecule, is a mitogen for keratinocytes. Squamous cell carcinoma (SCC) is a tumor derived from keratinoctyes. Expression of AR mRNA positively correlated with the clinical progression of 39 oral SCC. Oral SCC line, KB, was used as a model to study if increased expression of AR altered the biological behaviors of SCC cells. Exogenous AR dose-dependently enhanced the proliferation of KB cells expressing EGF receptor 1 (EGFR-1), a major receptor for AR, but little AR. Neutralizing anti-AR antibody significantly reversed the stimulatory effect of exogenous AR on KB cell proliferation. Ectopically expressed AR in stable clones manifested higher abilities to proliferate, migrate and invade Matrigel than vector control. Cyclooxygenase 2 (COX-2), but not metalloprotease 9 (MMP-9) mRNA, was increased in all the AR-expressing stable clones. In summary, AR behaves as a tumor promoter for oral SCC cells partly via increased expression of COX-2.

Original languageEnglish
Pages (from-to)381-390
Number of pages10
JournalOral Oncology
Volume42
Issue number4
DOIs
Publication statusPublished - 2006 Apr

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

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