Three structurally related khellactone coumarins, 1-3, were isolated from the aerial pans of Peucedanum japonicum (Umbelliferae). Compound 2 was identified as a new coumarin (cis-3′-isovalery-4′-senecioylkhellactone) by spectral and chemical analysis. Conformation of the dihydropyrano ring of cis-3′,4′-disenecioylkhellactone  was elucidated by X-ray crystallographic analysis. These three natural khellactone esters were subjected to the antiplatelet aggregation bioassay where cis-3′,4′-diisovalerylkhellactone  showed significant activity (at 50 μg/ml).
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry