An antiplatelet aggregation principle and X-ray structural analysis of cis-khellactone diester from peucedanum japonicum

Ting Ting Jong; Hwey Ching Hwang; Meei Yueh Jean; Tian Shung Wu; Che Ming Teng

doi:10.1021/np50088a002

An antiplatelet aggregation principle and X-ray structural analysis of cis-khellactone diester from peucedanum japonicum

Ting Ting Jong, Hwey Ching Hwang, Meei Yueh Jean, Tian Shung Wu, Che Ming Teng

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Three structurally related khellactone coumarins, 1-3, were isolated from the aerial pans of Peucedanum japonicum (Umbelliferae). Compound 2 was identified as a new coumarin (cis-3′-isovalery-4′-senecioylkhellactone) by spectral and chemical analysis. Conformation of the dihydropyrano ring of cis-3′,4′-disenecioylkhellactone [3] was elucidated by X-ray crystallographic analysis. These three natural khellactone esters were subjected to the antiplatelet aggregation bioassay where cis-3′,4′-diisovalerylkhellactone [1] showed significant activity (at 50 μg/ml).

Original language	English
Pages (from-to)	1396-1401
Number of pages	6
Journal	Journal of Natural Products
Volume	55
Issue number	10
DOIs	https://doi.org/10.1021/np50088a002
Publication status	Published - 1992 Oct 1

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "An antiplatelet aggregation principle and X-ray structural analysis of cis-khellactone diester from peucedanum japonicum",

abstract = "Three structurally related khellactone coumarins, 1-3, were isolated from the aerial pans of Peucedanum japonicum (Umbelliferae). Compound 2 was identified as a new coumarin (cis-3′-isovalery-4′-senecioylkhellactone) by spectral and chemical analysis. Conformation of the dihydropyrano ring of cis-3′,4′-disenecioylkhellactone [3] was elucidated by X-ray crystallographic analysis. These three natural khellactone esters were subjected to the antiplatelet aggregation bioassay where cis-3′,4′-diisovalerylkhellactone [1] showed significant activity (at 50 μg/ml).",

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AU - Wu, Tian Shung

AU - Teng, Che Ming

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AB - Three structurally related khellactone coumarins, 1-3, were isolated from the aerial pans of Peucedanum japonicum (Umbelliferae). Compound 2 was identified as a new coumarin (cis-3′-isovalery-4′-senecioylkhellactone) by spectral and chemical analysis. Conformation of the dihydropyrano ring of cis-3′,4′-disenecioylkhellactone [3] was elucidated by X-ray crystallographic analysis. These three natural khellactone esters were subjected to the antiplatelet aggregation bioassay where cis-3′,4′-diisovalerylkhellactone [1] showed significant activity (at 50 μg/ml).

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An antiplatelet aggregation principle and X-ray structural analysis of cis-khellactone diester from peucedanum japonicum

Abstract

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