An antiplatelet aggregation principle and X-ray structural analysis of cis-khellactone diester from peucedanum japonicum

Ting Ting Jong, Hwey Ching Hwang, Meei Yueh Jean, Tian Shung Wu, Che Ming Teng

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Three structurally related khellactone coumarins, 1-3, were isolated from the aerial pans of Peucedanum japonicum (Umbelliferae). Compound 2 was identified as a new coumarin (cis-3′-isovalery-4′-senecioylkhellactone) by spectral and chemical analysis. Conformation of the dihydropyrano ring of cis-3′,4′-disenecioylkhellactone [3] was elucidated by X-ray crystallographic analysis. These three natural khellactone esters were subjected to the antiplatelet aggregation bioassay where cis-3′,4′-diisovalerylkhellactone [1] showed significant activity (at 50 μg/ml).

Original languageEnglish
Pages (from-to)1396-1401
Number of pages6
JournalJournal of Natural Products
Volume55
Issue number10
DOIs
Publication statusPublished - 1992 Oct 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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