An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold

Hui Yi Shiao, Ching Chuan Kuo, Jim Tong Horng, Shin Ru Shih, Sui Yuan Chang, Chun Chen Liao, John T.A. Hsu, Prashanth Kumar Amancha, Yu Sheng Chao, Hsing Pang Hsieh

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

An efficient, mild and scalable synthesis of angelicin scaffold based compounds was developed. Particularly, the new synthetic route described here circumvents the need for the previously reported key Fries rearrangement step, which uses impractically harsh conditions. The new methodology is applied to the synthesis of several, previously reported analogs of angelicin which have potent anti-influenza and anti-cancer activities.

Original languageEnglish
Pages (from-to)1548-1554
Number of pages7
JournalJournal of the Chinese Chemical Society
Volume59
Issue number12
DOIs
Publication statusPublished - 2012 Dec

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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