An efficient synthesis of a potent anti-inflammatory agent, viscolin, and its inducible nitric oxide synthase inhibitory activity

Ping Chung Kuo, Yi Hsien Chen, Yann Lii Leu, Chieh Hung Huang, Yu Ren Liao, E. Jian Lee, Mei Lin Yang, Tian-Shung Wu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A new and efficient synthetic pathway employed the aldol condensation between the acetophenone (3) and vanillin derivative (4) resulted in the precursor chalcone intermediate (14). The target compound viscolin (1) could be afforded through the hydrogenation of the chalcone and followed by deprotection. The present strategy described the development of a more efficient procedure that allowed large-scale production of viscolin for the further research of biological activity both in vitro and in vivo.

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume60
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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