An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection

Tsung Ting Tsai, Yi Jui Chuang, Yee Shin Lin, Shu Wen Wan, Chia Ling Chen, Chiou Feng Lin

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms for DENV are complicated, involving viral cytotoxicity, immunopathogenesis, autoimmunity, and underlying host diseases. Viral load correlates with disease severity, while the antibody-dependent enhancement of infection largely determines the secondary effects of DENV infection. Epidemiological and experimental studies have revealed an association between the plasma levels of interleukin (IL)-10, which is the master anti-inflammatory cytokine, and disease severity in patients with DENV infection. Based on current knowledge of IL-10-mediated immune regulation during infection, researchers speculate an emerging role for IL-10 in clinical disease prognosis and dengue pathogenesis. However, the regulation of dengue pathogenesis has not been fully elucidated. This review article discusses the regulation and implications of IL-10 in DENV infection. For future strategies against DENV infection, manipulating IL-10 may be an effective antiviral treatment in addition to the development of a safe dengue vaccine.

Original languageEnglish
Article number40
JournalJournal of biomedical science
Volume20
Issue number1
DOIs
Publication statusPublished - 2013 Jun 27

Fingerprint

Dengue Virus
Virus Diseases
Viruses
Interleukin-10
Severe Dengue
Anti-Inflammatory Agents
Cytokines
Dengue
Antibody-Dependent Enhancement
Dengue Vaccines
Infection
Cytotoxicity
Viral Load
Autoimmunity
Antiviral Agents
Epidemiologic Studies
Research Personnel
Plasmas
Antibodies

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Tsai, Tsung Ting ; Chuang, Yi Jui ; Lin, Yee Shin ; Wan, Shu Wen ; Chen, Chia Ling ; Lin, Chiou Feng. / An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection. In: Journal of biomedical science. 2013 ; Vol. 20, No. 1.
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An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection. / Tsai, Tsung Ting; Chuang, Yi Jui; Lin, Yee Shin; Wan, Shu Wen; Chen, Chia Ling; Lin, Chiou Feng.

In: Journal of biomedical science, Vol. 20, No. 1, 40, 27.06.2013.

Research output: Contribution to journalReview article

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AU - Tsai, Tsung Ting

AU - Chuang, Yi Jui

AU - Lin, Yee Shin

AU - Wan, Shu Wen

AU - Chen, Chia Ling

AU - Lin, Chiou Feng

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AB - Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms for DENV are complicated, involving viral cytotoxicity, immunopathogenesis, autoimmunity, and underlying host diseases. Viral load correlates with disease severity, while the antibody-dependent enhancement of infection largely determines the secondary effects of DENV infection. Epidemiological and experimental studies have revealed an association between the plasma levels of interleukin (IL)-10, which is the master anti-inflammatory cytokine, and disease severity in patients with DENV infection. Based on current knowledge of IL-10-mediated immune regulation during infection, researchers speculate an emerging role for IL-10 in clinical disease prognosis and dengue pathogenesis. However, the regulation of dengue pathogenesis has not been fully elucidated. This review article discusses the regulation and implications of IL-10 in DENV infection. For future strategies against DENV infection, manipulating IL-10 may be an effective antiviral treatment in addition to the development of a safe dengue vaccine.

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