An exception of Eschweiler-Clarke methylation was found for α-amino amides. The α-amino amides on treatment with formaldehyde and formic acid produce cyclocondensation products, imidazolidin-4-ones, but N-methylation process becomes important when three substituents of the α-amino amides are very bulky. On the other hand, N-methylation is the only product for Eschweiler-Clarke methylation of the α-amino amides with N,N-disubstituted amide.
All Science Journal Classification (ASJC) codes
- Organic Chemistry