TY - JOUR
T1 - An exception of Eschweiler-Clarke methylation
T2 - Cyclocondensation of α-amino amides with formaldehyde and formic acid
AU - Chen, Fu Lin
AU - Sung, Kuangsen
PY - 2004/1/1
Y1 - 2004/1/1
N2 - An exception of Eschweiler-Clarke methylation was found for α-amino amides. The α-amino amides on treatment with formaldehyde and formic acid produce cyclocondensation products, imidazolidin-4-ones, but N-methylation process becomes important when three substituents of the α-amino amides are very bulky. On the other hand, N-methylation is the only product for Eschweiler-Clarke methylation of the α-amino amides with N,N-disubstituted amide.
AB - An exception of Eschweiler-Clarke methylation was found for α-amino amides. The α-amino amides on treatment with formaldehyde and formic acid produce cyclocondensation products, imidazolidin-4-ones, but N-methylation process becomes important when three substituents of the α-amino amides are very bulky. On the other hand, N-methylation is the only product for Eschweiler-Clarke methylation of the α-amino amides with N,N-disubstituted amide.
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U2 - 10.1002/jhet.5570410507
DO - 10.1002/jhet.5570410507
M3 - Article
AN - SCOPUS:6344269855
SN - 0022-152X
VL - 41
SP - 697
EP - 700
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 5
ER -