An immunoassay using platinum nanoparticles, silver enhancement and a electrodes chips

Kuei Ling Su, I. Long Wang, Po Yu Tu, Yung Chiang Chung, Yu-Cheng Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports a novel immunoassay using an electro-microchip to detect the immuno-reaction signal and the silver enhancement reaction to magnify the detection signal. Moreover, platinum nanoparticles (PtNPs) play the roles of a label for antigen or antibody and a catalyst for silver precipitation. The change of the impedance to corroborate immuno-reaction is detected, amplified and analyzed. The developed method shows that a chip with a 50 μm length 150 μm electrodes gap size has the highest sensitivity. Therefore, using an electro-microchip, antibody-PtNPs conjugates and a silver enhancement reaction, a new immunoassay is successfully constructed.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1008-1011
Number of pages4
ISBN (Print)9780979806421
Publication statusPublished - 2009 Jan 1
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
Country/TerritoryKorea, Republic of
CityJeju
Period09-11-0109-11-05

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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