AN INTEGRATED MICROFLUIDIC DEVICE FOR AUTOMATED DETECTION OF CANCER CELLS FROM BILE FOR CHOLANGIOCARCINOMA PROGNOSIS

Jui Lin Chang; Yi Cheng Tsai; Nai Jung Chiang; Chien Jui Huang; Yu Shan Huang; Shang Cheng Hung; Yan Shen Shan; Gwo Bin Lee

AN INTEGRATED MICROFLUIDIC DEVICE FOR AUTOMATED DETECTION OF CANCER CELLS FROM BILE FOR CHOLANGIOCARCINOMA PROGNOSIS

Jui Lin Chang
, Yi Cheng Tsai
, Nai Jung Chiang
, Chien Jui Huang
, Yu Shan Huang
, Shang Cheng Hung
, Yan Shen Shan
, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Cholangiocarcinoma (CCA) is difficult to detect due to its deep location and has recognized as “silent” cancer. Blood has been commonly used for liquid biopsy; however, accuracy of this approach was not satisfactory. In this study, we hypothesized bile could be a reliable sample for CCA detection/prognosis since it is relatively closer to lesions. We herein developed a new integrated microfluidic system which could simultaneously utilize three affinity reagents to capture tumor cells. Experimental results showed these affinity reagents captured tumor cells successfully in 2-ml bile with a sensitivity of 100% and a specificity of 79.3% from 119 clinical samples.

Original language	English
Title of host publication	MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	229-230
Number of pages	2
ISBN (Electronic)	9781733419048
Publication status	Published - 2022
Event	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 - Hybrid, Hangzhou, China Duration: 2022 Oct 23 → 2022 Oct 27

Publication series

Name	MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022
Country/Territory	China
City	Hybrid, Hangzhou
Period	22-10-23 → 22-10-27

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Chemical Engineering (miscellaneous)
Bioengineering
General Chemistry
Control and Systems Engineering

Cite this

Chang, J. L., Tsai, Y. C., Chiang, N. J., Huang, C. J., Huang, Y. S., Hung, S. C., Shan, Y. S., & Lee, G. B. (2022). AN INTEGRATED MICROFLUIDIC DEVICE FOR AUTOMATED DETECTION OF CANCER CELLS FROM BILE FOR CHOLANGIOCARCINOMA PROGNOSIS. In MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 229-230). (MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.

Chang, Jui Lin ; Tsai, Yi Cheng ; Chiang, Nai Jung et al. / AN INTEGRATED MICROFLUIDIC DEVICE FOR AUTOMATED DETECTION OF CANCER CELLS FROM BILE FOR CHOLANGIOCARCINOMA PROGNOSIS. MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2022. pp. 229-230 (MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

@inproceedings{11dca71243dd4689b34813bed25d472f,

title = "AN INTEGRATED MICROFLUIDIC DEVICE FOR AUTOMATED DETECTION OF CANCER CELLS FROM BILE FOR CHOLANGIOCARCINOMA PROGNOSIS",

abstract = "Cholangiocarcinoma (CCA) is difficult to detect due to its deep location and has recognized as “silent” cancer. Blood has been commonly used for liquid biopsy; however, accuracy of this approach was not satisfactory. In this study, we hypothesized bile could be a reliable sample for CCA detection/prognosis since it is relatively closer to lesions. We herein developed a new integrated microfluidic system which could simultaneously utilize three affinity reagents to capture tumor cells. Experimental results showed these affinity reagents captured tumor cells successfully in 2-ml bile with a sensitivity of 100\% and a specificity of 79.3\% from 119 clinical samples.",

author = "Chang, \{Jui Lin\} and Tsai, \{Yi Cheng\} and Chiang, \{Nai Jung\} and Huang, \{Chien Jui\} and Huang, \{Yu Shan\} and Hung, \{Shang Cheng\} and Shan, \{Yan Shen\} and Lee, \{Gwo Bin\}",

note = "Publisher Copyright: {\textcopyright} 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 ; Conference date: 23-10-2022 Through 27-10-2022",

year = "2022",

language = "English",

series = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Chemical and Biological Microsystems Society",

pages = "229--230",

booktitle = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

}

Chang, JL, Tsai, YC, Chiang, NJ, Huang, CJ, Huang, YS, Hung, SC, Shan, YS & Lee, GB 2022, AN INTEGRATED MICROFLUIDIC DEVICE FOR AUTOMATED DETECTION OF CANCER CELLS FROM BILE FOR CHOLANGIOCARCINOMA PROGNOSIS. in MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 229-230, 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022, Hybrid, Hangzhou, China, 22-10-23.

AN INTEGRATED MICROFLUIDIC DEVICE FOR AUTOMATED DETECTION OF CANCER CELLS FROM BILE FOR CHOLANGIOCARCINOMA PROGNOSIS. / Chang, Jui Lin; Tsai, Yi Cheng; Chiang, Nai Jung et al.
MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2022. p. 229-230 (MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - AN INTEGRATED MICROFLUIDIC DEVICE FOR AUTOMATED DETECTION OF CANCER CELLS FROM BILE FOR CHOLANGIOCARCINOMA PROGNOSIS

AU - Chang, Jui Lin

AU - Tsai, Yi Cheng

AU - Chiang, Nai Jung

AU - Huang, Chien Jui

AU - Huang, Yu Shan

AU - Hung, Shang Cheng

AU - Shan, Yan Shen

AU - Lee, Gwo Bin

PY - 2022

Y1 - 2022

N2 - Cholangiocarcinoma (CCA) is difficult to detect due to its deep location and has recognized as “silent” cancer. Blood has been commonly used for liquid biopsy; however, accuracy of this approach was not satisfactory. In this study, we hypothesized bile could be a reliable sample for CCA detection/prognosis since it is relatively closer to lesions. We herein developed a new integrated microfluidic system which could simultaneously utilize three affinity reagents to capture tumor cells. Experimental results showed these affinity reagents captured tumor cells successfully in 2-ml bile with a sensitivity of 100% and a specificity of 79.3% from 119 clinical samples.

AB - Cholangiocarcinoma (CCA) is difficult to detect due to its deep location and has recognized as “silent” cancer. Blood has been commonly used for liquid biopsy; however, accuracy of this approach was not satisfactory. In this study, we hypothesized bile could be a reliable sample for CCA detection/prognosis since it is relatively closer to lesions. We herein developed a new integrated microfluidic system which could simultaneously utilize three affinity reagents to capture tumor cells. Experimental results showed these affinity reagents captured tumor cells successfully in 2-ml bile with a sensitivity of 100% and a specificity of 79.3% from 119 clinical samples.

UR - https://www.scopus.com/pages/publications/85175696841

UR - https://www.scopus.com/pages/publications/85175696841#tab=citedBy

M3 - Conference contribution

AN - SCOPUS:85175696841

T3 - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

SP - 229

EP - 230

BT - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

Y2 - 23 October 2022 through 27 October 2022

ER -

Chang JL, Tsai YC, Chiang NJ, Huang CJ, Huang YS, Hung SC et al. AN INTEGRATED MICROFLUIDIC DEVICE FOR AUTOMATED DETECTION OF CANCER CELLS FROM BILE FOR CHOLANGIOCARCINOMA PROGNOSIS. In MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2022. p. 229-230. (MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

AN INTEGRATED MICROFLUIDIC DEVICE FOR AUTOMATED DETECTION OF CANCER CELLS FROM BILE FOR CHOLANGIOCARCINOMA PROGNOSIS

Abstract

Publication series

Conference

UN SDGs

All Science Journal Classification (ASJC) codes

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Cite this