An integrated microfluidic platform for chromosomal analysis

Chien Hsuan Tai, Ya Lan Chen, Chung-Liang Ho, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The fluorescence in situ hybridization (FISH) technique has been commonly employed to determine chromosomal abnormalities. However, it still requires lengthy and labor-intensive sample preparation process. In this study, a new microfluidic chip capable of performing the entire FISH protocol automatically was reported. When compared with the traditional method, several advantages including reduced consumption of biosamples and reagents, automation, fast analysis, can be achieved. Experimental data demonstrated that the developed system can successfully provide superior performance for probing the genetic content of cells at the chromosomal abnormality.

Original languageEnglish
Title of host publication2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Pages918-921
Number of pages4
DOIs
Publication statusPublished - 2012
Event2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France
Duration: 2012 Jan 292012 Feb 2

Other

Other2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
CountryFrance
CityParis
Period12-01-2912-02-02

Fingerprint

abnormalities
Microfluidics
platforms
Fluorescence
fluorescence
labor
automation
reagents
Automation
chips
Personnel
preparation
cells

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Tai, C. H., Chen, Y. L., Ho, C-L., & Lee, G. B. (2012). An integrated microfluidic platform for chromosomal analysis. In 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 (pp. 918-921). [6170335] https://doi.org/10.1109/MEMSYS.2012.6170335
Tai, Chien Hsuan ; Chen, Ya Lan ; Ho, Chung-Liang ; Lee, Gwo Bin. / An integrated microfluidic platform for chromosomal analysis. 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012. 2012. pp. 918-921
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Tai, CH, Chen, YL, Ho, C-L & Lee, GB 2012, An integrated microfluidic platform for chromosomal analysis. in 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012., 6170335, pp. 918-921, 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012, Paris, France, 12-01-29. https://doi.org/10.1109/MEMSYS.2012.6170335

An integrated microfluidic platform for chromosomal analysis. / Tai, Chien Hsuan; Chen, Ya Lan; Ho, Chung-Liang; Lee, Gwo Bin.

2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012. 2012. p. 918-921 6170335.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - The fluorescence in situ hybridization (FISH) technique has been commonly employed to determine chromosomal abnormalities. However, it still requires lengthy and labor-intensive sample preparation process. In this study, a new microfluidic chip capable of performing the entire FISH protocol automatically was reported. When compared with the traditional method, several advantages including reduced consumption of biosamples and reagents, automation, fast analysis, can be achieved. Experimental data demonstrated that the developed system can successfully provide superior performance for probing the genetic content of cells at the chromosomal abnormality.

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Tai CH, Chen YL, Ho C-L, Lee GB. An integrated microfluidic platform for chromosomal analysis. In 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012. 2012. p. 918-921. 6170335 https://doi.org/10.1109/MEMSYS.2012.6170335