An integrated microfluidic platform for chromosomal analysis

Chien Hsuan Tai; Ya Lan Chen; Chung-Liang Ho; Gwo Bin Lee

doi:10.1109/MEMSYS.2012.6170335

An integrated microfluidic platform for chromosomal analysis

Chien Hsuan Tai, Ya Lan Chen, Chung-Liang Ho, Gwo Bin Lee

Department of Pathology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

The fluorescence in situ hybridization (FISH) technique has been commonly employed to determine chromosomal abnormalities. However, it still requires lengthy and labor-intensive sample preparation process. In this study, a new microfluidic chip capable of performing the entire FISH protocol automatically was reported. When compared with the traditional method, several advantages including reduced consumption of biosamples and reagents, automation, fast analysis, can be achieved. Experimental data demonstrated that the developed system can successfully provide superior performance for probing the genetic content of cells at the chromosomal abnormality.

Original language	English
Title of host publication	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Pages	918-921
Number of pages	4
DOIs	https://doi.org/10.1109/MEMSYS.2012.6170335
Publication status	Published - 2012
Event	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France Duration: 2012 Jan 29 → 2012 Feb 2

Other

Other	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Country	France
City	Paris
Period	12-01-29 → 12-02-02

All Science Journal Classification (ASJC) codes

Electrical and Electronic Engineering
Mechanical Engineering
Condensed Matter Physics
Electronic, Optical and Magnetic Materials

Access to Document

10.1109/MEMSYS.2012.6170335

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title = "An integrated microfluidic platform for chromosomal analysis",

abstract = "The fluorescence in situ hybridization (FISH) technique has been commonly employed to determine chromosomal abnormalities. However, it still requires lengthy and labor-intensive sample preparation process. In this study, a new microfluidic chip capable of performing the entire FISH protocol automatically was reported. When compared with the traditional method, several advantages including reduced consumption of biosamples and reagents, automation, fast analysis, can be achieved. Experimental data demonstrated that the developed system can successfully provide superior performance for probing the genetic content of cells at the chromosomal abnormality.",

author = "Tai, {Chien Hsuan} and Chen, {Ya Lan} and Chung-Liang Ho and Lee, {Gwo Bin}",

year = "2012",

doi = "10.1109/MEMSYS.2012.6170335",

language = "English",

isbn = "9781467303248",

pages = "918--921",

booktitle = "2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012",

note = "2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 ; Conference date: 29-01-2012 Through 02-02-2012",

}

Tai, CH, Chen, YL, Ho, C-L & Lee, GB 2012, An integrated microfluidic platform for chromosomal analysis. in 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012., 6170335, pp. 918-921, 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012, Paris, France, 12-01-29. https://doi.org/10.1109/MEMSYS.2012.6170335

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AU - Tai, Chien Hsuan

AU - Chen, Ya Lan

AU - Ho, Chung-Liang

AU - Lee, Gwo Bin

PY - 2012

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N2 - The fluorescence in situ hybridization (FISH) technique has been commonly employed to determine chromosomal abnormalities. However, it still requires lengthy and labor-intensive sample preparation process. In this study, a new microfluidic chip capable of performing the entire FISH protocol automatically was reported. When compared with the traditional method, several advantages including reduced consumption of biosamples and reagents, automation, fast analysis, can be achieved. Experimental data demonstrated that the developed system can successfully provide superior performance for probing the genetic content of cells at the chromosomal abnormality.

AB - The fluorescence in situ hybridization (FISH) technique has been commonly employed to determine chromosomal abnormalities. However, it still requires lengthy and labor-intensive sample preparation process. In this study, a new microfluidic chip capable of performing the entire FISH protocol automatically was reported. When compared with the traditional method, several advantages including reduced consumption of biosamples and reagents, automation, fast analysis, can be achieved. Experimental data demonstrated that the developed system can successfully provide superior performance for probing the genetic content of cells at the chromosomal abnormality.

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BT - 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012

T2 - 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012

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