An integrated microfluidic system for continuous selection of aptamers by using tissue samples

Wei Ting Liu, Wen Bin Lee, Yi Cheng Tsai, Lien Yu Hung, Chien Yu Fu, Yuan Jhe Chuang, Keng Fu Hsu, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work, an integrated microfluidic system was presented to select specific aptamers by performing a tissue-based systematic evolution of ligands by exponential enrichment (Tissue-SELEX) in a continuous format. Ovarian cancer tissue slides were used as the target to screen the cancer-specific aptamers. This system was consisted of a flow control module, a temperature control module and an integrated microfluidic chip. The Tissue-SELEX processes could be automatically carried out on the developed microfluidic system.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1435-1436
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2020 Jan 1
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 2017 Oct 222017 Oct 26

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period17-10-2217-10-26

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All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Liu, W. T., Lee, W. B., Tsai, Y. C., Hung, L. Y., Fu, C. Y., Chuang, Y. J., Hsu, K. F., & Lee, G. B. (2020). An integrated microfluidic system for continuous selection of aptamers by using tissue samples. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1435-1436). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.