An integrated microfluidic system for rapid HbA1c measurement

Ching Chu Wu, Ko Wei Chang, Hsin I. Lin, Shu-Chu Shiesh, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Diabetes mellitus (DM) is one of the most prevalent diseases and easily lead to serious complications. Glycosylated hemoglobin (HbA1c), an emerging biomarker for reliable monitoring of DM is commonly detected by bench-top immunoassays, which are labor-intensive and time-consuming. As an advance to existing methods, a microfluidic platform capable of performing automated immunoassay for HbA1c detection within 25 minutes is presented in this work. The microfluidic assay was able to detect HbA1c from human whole blood samples and delivered similar performance as its bench-top counterpart. The developed microfluidic chip is therefore promising for rapid detection of HbA1c for monitoring DM.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages684-686
Number of pages3
ISBN (Print)9781632666246
Publication statusPublished - 2013 Jan 1
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 2013 Oct 272013 Oct 31

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume1

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period13-10-2713-10-31

Fingerprint

Medical problems
Microfluidics
Monitoring
Hemoglobin
Glycosylated Hemoglobin A
Biomarkers
Assays
Blood
Personnel

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Wu, C. C., Chang, K. W., Lin, H. I., Shiesh, S-C., & Lee, G. B. (2013). An integrated microfluidic system for rapid HbA1c measurement. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (pp. 684-686). (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Vol. 1). Chemical and Biological Microsystems Society.
Wu, Ching Chu ; Chang, Ko Wei ; Lin, Hsin I. ; Shiesh, Shu-Chu ; Lee, Gwo Bin. / An integrated microfluidic system for rapid HbA1c measurement. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, 2013. pp. 684-686 (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013).
@inproceedings{f4ccf29e5a5d44d3bcba408bb7e33cc4,
title = "An integrated microfluidic system for rapid HbA1c measurement",
abstract = "Diabetes mellitus (DM) is one of the most prevalent diseases and easily lead to serious complications. Glycosylated hemoglobin (HbA1c), an emerging biomarker for reliable monitoring of DM is commonly detected by bench-top immunoassays, which are labor-intensive and time-consuming. As an advance to existing methods, a microfluidic platform capable of performing automated immunoassay for HbA1c detection within 25 minutes is presented in this work. The microfluidic assay was able to detect HbA1c from human whole blood samples and delivered similar performance as its bench-top counterpart. The developed microfluidic chip is therefore promising for rapid detection of HbA1c for monitoring DM.",
author = "Wu, {Ching Chu} and Chang, {Ko Wei} and Lin, {Hsin I.} and Shu-Chu Shiesh and Lee, {Gwo Bin}",
year = "2013",
month = "1",
day = "1",
language = "English",
isbn = "9781632666246",
series = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
publisher = "Chemical and Biological Microsystems Society",
pages = "684--686",
booktitle = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",

}

Wu, CC, Chang, KW, Lin, HI, Shiesh, S-C & Lee, GB 2013, An integrated microfluidic system for rapid HbA1c measurement. in 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, vol. 1, Chemical and Biological Microsystems Society, pp. 684-686, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, Freiburg, Germany, 13-10-27.

An integrated microfluidic system for rapid HbA1c measurement. / Wu, Ching Chu; Chang, Ko Wei; Lin, Hsin I.; Shiesh, Shu-Chu; Lee, Gwo Bin.

17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, 2013. p. 684-686 (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - An integrated microfluidic system for rapid HbA1c measurement

AU - Wu, Ching Chu

AU - Chang, Ko Wei

AU - Lin, Hsin I.

AU - Shiesh, Shu-Chu

AU - Lee, Gwo Bin

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Diabetes mellitus (DM) is one of the most prevalent diseases and easily lead to serious complications. Glycosylated hemoglobin (HbA1c), an emerging biomarker for reliable monitoring of DM is commonly detected by bench-top immunoassays, which are labor-intensive and time-consuming. As an advance to existing methods, a microfluidic platform capable of performing automated immunoassay for HbA1c detection within 25 minutes is presented in this work. The microfluidic assay was able to detect HbA1c from human whole blood samples and delivered similar performance as its bench-top counterpart. The developed microfluidic chip is therefore promising for rapid detection of HbA1c for monitoring DM.

AB - Diabetes mellitus (DM) is one of the most prevalent diseases and easily lead to serious complications. Glycosylated hemoglobin (HbA1c), an emerging biomarker for reliable monitoring of DM is commonly detected by bench-top immunoassays, which are labor-intensive and time-consuming. As an advance to existing methods, a microfluidic platform capable of performing automated immunoassay for HbA1c detection within 25 minutes is presented in this work. The microfluidic assay was able to detect HbA1c from human whole blood samples and delivered similar performance as its bench-top counterpart. The developed microfluidic chip is therefore promising for rapid detection of HbA1c for monitoring DM.

UR - http://www.scopus.com/inward/record.url?scp=84907355121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907355121&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84907355121

SN - 9781632666246

T3 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013

SP - 684

EP - 686

BT - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013

PB - Chemical and Biological Microsystems Society

ER -

Wu CC, Chang KW, Lin HI, Shiesh S-C, Lee GB. An integrated microfluidic system for rapid HbA1c measurement. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society. 2013. p. 684-686. (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013).