An integrated selex microfluidic system for rapid screening of influenza virus-specific aptamers

Hsien Chih Lai, Chih Hung Wang, Chen-Hsun Weng, Tong Miin Liou, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

An integrated microfluidic system was developed to automatically perform systematic evolution of ligands and exponential enrichment (SELEX) process using combinational single-stranded DNA (ssDNA) library for rapid screening of highly specific aptamers for influenza viruses in this study. This integrated microfluidic system consisted of several modules on a single chip. With this system, the specific aptamers were screened successfully with high affinity for influenza viruses after several repeated extraction and amplification runs. Therefore, it may provide a useful platform for specific aptamers screening, which can be a promising biomarker to recognize viruses for fast diagnosis.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1402-1404
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012 Jan 1
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 2012 Oct 282012 Nov 1

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period12-10-2812-11-01

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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