An overview of microbiome based strategies on anti-obesity

Cherng Shyang Chang, Jhen-Wei Ruan, Cheng Yuan Kao

Research output: Contribution to journalReview article

Abstract

With the significant global obesity epidemic and emerging strong scientific evidence that connected gut microbiota to obesity, intervening obesity by targeting gut microbiota has become a trendy strategy. Particularly the application of probiotics has become remarkably popular because of their expected association with gut microbiota modulation. Although there are many literatures on the effects of probiotics in obese animal models, most of them reported the effects of probiotic bacteria on metabolic indications with limited information on anti-obesity itself. Besides, some probiotics have been shown to reduce certain metabolic symptoms but they failed to achieve weight loss. This report reviewed the current literatures on the anti-obesity effects of next-generation probiotics in various animal obesity models and discussed the beneficial potential of fecal microbiota transplantation in treating obesity in humans. The purpose of this article is to help guide further research improve the probiotic bacteria experiments in more precise animal obesity models by standardizing the anti-obesogenesis, obesity control, and treatment assays and hopefully the evidence-based investigations on harnessing gut microbiota through next-generation probiotics or fecal microbiota transplantation will develop new interventions to promote and achieve anti-obesity.

Original languageEnglish
Pages (from-to)7-16
Number of pages10
JournalKaohsiung Journal of Medical Sciences
Volume35
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Microbiota
Obesity
Probiotics
Animal Models
Bacteria
Cohort Effect
Weight Loss
Gastrointestinal Microbiome

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chang, Cherng Shyang ; Ruan, Jhen-Wei ; Kao, Cheng Yuan. / An overview of microbiome based strategies on anti-obesity. In: Kaohsiung Journal of Medical Sciences. 2019 ; Vol. 35, No. 1. pp. 7-16.
@article{1754c6480a554a28b3f8281326dc1fd7,
title = "An overview of microbiome based strategies on anti-obesity",
abstract = "With the significant global obesity epidemic and emerging strong scientific evidence that connected gut microbiota to obesity, intervening obesity by targeting gut microbiota has become a trendy strategy. Particularly the application of probiotics has become remarkably popular because of their expected association with gut microbiota modulation. Although there are many literatures on the effects of probiotics in obese animal models, most of them reported the effects of probiotic bacteria on metabolic indications with limited information on anti-obesity itself. Besides, some probiotics have been shown to reduce certain metabolic symptoms but they failed to achieve weight loss. This report reviewed the current literatures on the anti-obesity effects of next-generation probiotics in various animal obesity models and discussed the beneficial potential of fecal microbiota transplantation in treating obesity in humans. The purpose of this article is to help guide further research improve the probiotic bacteria experiments in more precise animal obesity models by standardizing the anti-obesogenesis, obesity control, and treatment assays and hopefully the evidence-based investigations on harnessing gut microbiota through next-generation probiotics or fecal microbiota transplantation will develop new interventions to promote and achieve anti-obesity.",
author = "Chang, {Cherng Shyang} and Jhen-Wei Ruan and Kao, {Cheng Yuan}",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/kjm2.12010",
language = "English",
volume = "35",
pages = "7--16",
journal = "Kaohsiung Journal of Medical Sciences",
issn = "1607-551X",
publisher = "Elsevier (Singapore) Pte Ltd",
number = "1",

}

An overview of microbiome based strategies on anti-obesity. / Chang, Cherng Shyang; Ruan, Jhen-Wei; Kao, Cheng Yuan.

In: Kaohsiung Journal of Medical Sciences, Vol. 35, No. 1, 01.01.2019, p. 7-16.

Research output: Contribution to journalReview article

TY - JOUR

T1 - An overview of microbiome based strategies on anti-obesity

AU - Chang, Cherng Shyang

AU - Ruan, Jhen-Wei

AU - Kao, Cheng Yuan

PY - 2019/1/1

Y1 - 2019/1/1

N2 - With the significant global obesity epidemic and emerging strong scientific evidence that connected gut microbiota to obesity, intervening obesity by targeting gut microbiota has become a trendy strategy. Particularly the application of probiotics has become remarkably popular because of their expected association with gut microbiota modulation. Although there are many literatures on the effects of probiotics in obese animal models, most of them reported the effects of probiotic bacteria on metabolic indications with limited information on anti-obesity itself. Besides, some probiotics have been shown to reduce certain metabolic symptoms but they failed to achieve weight loss. This report reviewed the current literatures on the anti-obesity effects of next-generation probiotics in various animal obesity models and discussed the beneficial potential of fecal microbiota transplantation in treating obesity in humans. The purpose of this article is to help guide further research improve the probiotic bacteria experiments in more precise animal obesity models by standardizing the anti-obesogenesis, obesity control, and treatment assays and hopefully the evidence-based investigations on harnessing gut microbiota through next-generation probiotics or fecal microbiota transplantation will develop new interventions to promote and achieve anti-obesity.

AB - With the significant global obesity epidemic and emerging strong scientific evidence that connected gut microbiota to obesity, intervening obesity by targeting gut microbiota has become a trendy strategy. Particularly the application of probiotics has become remarkably popular because of their expected association with gut microbiota modulation. Although there are many literatures on the effects of probiotics in obese animal models, most of them reported the effects of probiotic bacteria on metabolic indications with limited information on anti-obesity itself. Besides, some probiotics have been shown to reduce certain metabolic symptoms but they failed to achieve weight loss. This report reviewed the current literatures on the anti-obesity effects of next-generation probiotics in various animal obesity models and discussed the beneficial potential of fecal microbiota transplantation in treating obesity in humans. The purpose of this article is to help guide further research improve the probiotic bacteria experiments in more precise animal obesity models by standardizing the anti-obesogenesis, obesity control, and treatment assays and hopefully the evidence-based investigations on harnessing gut microbiota through next-generation probiotics or fecal microbiota transplantation will develop new interventions to promote and achieve anti-obesity.

UR - http://www.scopus.com/inward/record.url?scp=85062616194&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062616194&partnerID=8YFLogxK

U2 - 10.1002/kjm2.12010

DO - 10.1002/kjm2.12010

M3 - Review article

VL - 35

SP - 7

EP - 16

JO - Kaohsiung Journal of Medical Sciences

JF - Kaohsiung Journal of Medical Sciences

SN - 1607-551X

IS - 1

ER -