Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men

Ping Feng Wu, Jen Fan Hang, Carol Strong, Su Jung Chen, Li Ya Lin, Shu Sheng Chen, Chiung Ru Lai, Stephane Wen Wei Ku, Mei Hsuan Lee

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Abstract

Human papillomavirus (HPV) infection contributes to most anal cancers and premalignant intraepithelial lesions. This study investigated anal HPV infections and cytological abnormalities among men who have sex with men (MSM). Sociodemographic characteristics and sexual behaviors were collected by using a structured questionnaire. Anal cytological results were examined, and HPV genotyping was performed by the Linear Array HPV Genotyping test. Logistic regression was used to estimate risk factors and their associations with high-risk HPV infection and cytological abnormalities. Among 163 MSM, 101 were seropositive for human immunodeficiency virus (HIV) and 62 were seronegative for HIV. The overall prevalence of HPV was 66.2%. A total of 61.9% and 48.2% of participants had never acquired any of either the quadrivalent or nonavalent vaccine HPV types, respectively. Cytological findings showed 15.3% atypical squamous cells of undetermined significance, 16.6% low-grade squamous intraepithelial lesion, 4.9% atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesion and 17% high-grade squamous intraepithelial lesion. The number of high-risk HPV types was the predominant risk factor for abnormal anal cytology (OR 2.02, 95% CI 1.27-3.24). Infection with high-risk HPV was a significant predictor for cytological abnormality. MSM should be encouraged to obtain the HPV vaccine.

Original languageEnglish
Number of pages1
JournalScientific reports
Volume10
Issue number1
DOIs
Publication statusPublished - 2020 Feb 21

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Wu, P. F., Hang, J. F., Strong, C., Chen, S. J., Lin, L. Y., Chen, S. S., Lai, C. R., Ku, S. W. W., & Lee, M. H. (2020). Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men. Scientific reports, 10(1). https://doi.org/10.1038/s41598-020-59967-4