TY - JOUR
T1 - Analogous amino acid sequences in myelin proteolipid and viral proteins
AU - Shaw, Shyh Yu
AU - Laursen, Richard A.
AU - Lees, Marjorie B.
N1 - Funding Information:
This work was supported by grants from the National Institutes of Health (NS-13649 and NS 16945) and National Science Foundation (DMB 85-03940).
PY - 1986/10/27
Y1 - 1986/10/27
N2 - Computer analysis of the intrinsic membrane protein, myelin proteolipid, shows strong sequence similarities between the putative extramembrane segments of the proteolipid protein and a number of viral proteins, several of which infect humans. These similarities are even more striking than those reported previously between viral proteins and the encephalitogenic myelin basic protein (MBP). These findings, along with other reports of molecular mimicry by viruses, suggest that immunological cross-reactions between virus-induced antibodies or T-cells and analogous antigenic determinants (epitopes) in myelin proteolipid could be involved in the pathophysiology of multiple sclerosis or post-infectious demyelinating syndromes.
AB - Computer analysis of the intrinsic membrane protein, myelin proteolipid, shows strong sequence similarities between the putative extramembrane segments of the proteolipid protein and a number of viral proteins, several of which infect humans. These similarities are even more striking than those reported previously between viral proteins and the encephalitogenic myelin basic protein (MBP). These findings, along with other reports of molecular mimicry by viruses, suggest that immunological cross-reactions between virus-induced antibodies or T-cells and analogous antigenic determinants (epitopes) in myelin proteolipid could be involved in the pathophysiology of multiple sclerosis or post-infectious demyelinating syndromes.
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U2 - 10.1016/0014-5793(86)81502-2
DO - 10.1016/0014-5793(86)81502-2
M3 - Article
C2 - 2429866
AN - SCOPUS:0023018974
SN - 0014-5793
VL - 207
SP - 266
EP - 270
JO - FEBS Letters
JF - FEBS Letters
IS - 2
ER -