Analysis for the dual-phase-lag bio-heat transfer during magnetic hyperthermia treatment

Kuo Chi Liu, Han-Taw Chen

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Magnetic fluid hyperthermia is one of hyperthermia modalities for tumor treatment. The control of temperatures is necessary and important for treatment quality. Living tissue is highly non-homogenous, and the velocity of heat transfer in it should be limited. Thus, this work analyzes the temperature rise behaviors in biological tissues during hyperthermia treatment within the dual-phase-lag model, which accounts the effect of local non-equilibrium on the thermal behavior. A small tumor surrounded by the health tissue is considered as a solid sphere. The influences of lag times, metabolic heat generation rate, blood perfusion rate, and other physiological parameters on the thermal response in tissues are investigated. While the metabolic heat generation takes little percentage of heating source, its effect on the temperature rise can be ignored. The control of the blood perfusion rate is helpful to have an ideal hyperthermia treatment. The lag times, τq and τT, affect the bio-heat transfer at the early times of heating. The total effect of τq and τT on the bio-heat transfer may be different for the same τTq value.

Original languageEnglish
Pages (from-to)1185-1192
Number of pages8
JournalInternational Journal of Heat and Mass Transfer
Volume52
Issue number5-6
DOIs
Publication statusPublished - 2009 Feb 1

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hyperthermia
time lag
heat transfer
Tissue
Heat transfer
heat generation
Heat generation
blood
Tumors
Blood
tumors
Heating
heating
Magnetic fluids
Temperature
health
temperature
Health
fluids
Hot Temperature

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering
  • Condensed Matter Physics
  • Fluid Flow and Transfer Processes

Cite this

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abstract = "Magnetic fluid hyperthermia is one of hyperthermia modalities for tumor treatment. The control of temperatures is necessary and important for treatment quality. Living tissue is highly non-homogenous, and the velocity of heat transfer in it should be limited. Thus, this work analyzes the temperature rise behaviors in biological tissues during hyperthermia treatment within the dual-phase-lag model, which accounts the effect of local non-equilibrium on the thermal behavior. A small tumor surrounded by the health tissue is considered as a solid sphere. The influences of lag times, metabolic heat generation rate, blood perfusion rate, and other physiological parameters on the thermal response in tissues are investigated. While the metabolic heat generation takes little percentage of heating source, its effect on the temperature rise can be ignored. The control of the blood perfusion rate is helpful to have an ideal hyperthermia treatment. The lag times, τq and τT, affect the bio-heat transfer at the early times of heating. The total effect of τq and τT on the bio-heat transfer may be different for the same τT/τq value.",
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Analysis for the dual-phase-lag bio-heat transfer during magnetic hyperthermia treatment. / Liu, Kuo Chi; Chen, Han-Taw.

In: International Journal of Heat and Mass Transfer, Vol. 52, No. 5-6, 01.02.2009, p. 1185-1192.

Research output: Contribution to journalArticle

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AB - Magnetic fluid hyperthermia is one of hyperthermia modalities for tumor treatment. The control of temperatures is necessary and important for treatment quality. Living tissue is highly non-homogenous, and the velocity of heat transfer in it should be limited. Thus, this work analyzes the temperature rise behaviors in biological tissues during hyperthermia treatment within the dual-phase-lag model, which accounts the effect of local non-equilibrium on the thermal behavior. A small tumor surrounded by the health tissue is considered as a solid sphere. The influences of lag times, metabolic heat generation rate, blood perfusion rate, and other physiological parameters on the thermal response in tissues are investigated. While the metabolic heat generation takes little percentage of heating source, its effect on the temperature rise can be ignored. The control of the blood perfusion rate is helpful to have an ideal hyperthermia treatment. The lag times, τq and τT, affect the bio-heat transfer at the early times of heating. The total effect of τq and τT on the bio-heat transfer may be different for the same τT/τq value.

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