Analysis of genes for alcoholism using two-disease-locus models

Chih Chieh Wu; Sanjay Shete

doi:10.1186/1471-2156-6-S1-S149

Analysis of genes for alcoholism using two-disease-locus models

Chih Chieh Wu, Sanjay Shete

Department of Environmental and Occupational Health

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Using model-based two-locus methods for mapping genes, we analyzed the family data from the Collaborative Study on the Genetics of Alcoholism. Microsatellite data from 143 families ascertained through having three or more individuals affected with alcohol dependence were used for this investigation. Four regions showing evidence for linkage were identified using single-locus models from previous investigations. We investigated the genetic linkage, pattern of disease inheritance, and pair-wise genetic epistasis of these loci using the TLINKAGE program for two-disease-locus analysis.

Original language	English
Article number	S149
Journal	BMC Genetics
Volume	6
Issue number	SUPPL.1
DOIs	https://doi.org/10.1186/1471-2156-6-S1-S149
Publication status	Published - 2005 Dec 30

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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10.1186/1471-2156-6-S1-S149

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AB - Using model-based two-locus methods for mapping genes, we analyzed the family data from the Collaborative Study on the Genetics of Alcoholism. Microsatellite data from 143 families ascertained through having three or more individuals affected with alcohol dependence were used for this investigation. Four regions showing evidence for linkage were identified using single-locus models from previous investigations. We investigated the genetic linkage, pattern of disease inheritance, and pair-wise genetic epistasis of these loci using the TLINKAGE program for two-disease-locus analysis.

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Analysis of genes for alcoholism using two-disease-locus models

Abstract

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