TY - JOUR
T1 - Analysis of microparticle deposition in the human lung by taguchi method and response surface methodology
AU - Chen, Wei Hsin
AU - Chang, Che Ming
AU - Mutuku, Justus Kavita
AU - Lam, Su Shiung
AU - Lee, Wen Jhy
N1 - Funding Information:
The authors acknowledge financial support from the Ministry of Science and Technology Taiwan, ROC, under the grant numbers MOST 108-2622-E-006-017-CC1 and 109-3116-F-006-016-CC1 for this research. Additionally, the authors would also like to thank Universiti Malaysia Terengganu under Golden Goose Research Grant Scheme (GGRG) ( UMT/RMIC/2-2/25 Jld 5 (64), Vot 55191 ) and HICoE AKUATROP Trust Account No. 66955 for supporting Prof. Lam to perform this joint project with National Cheng Kung University.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/6
Y1 - 2021/6
N2 - The deposition phenomenon of microparticle and SAR-CoV-2 laced bioaerosol in human airways is studied by Taguchi methods and response surface methodology (RSM). The data used herein is obtained from simulations of airflow dynamics and deposition fractions of drug particle aerosols in the downstream airways of asthma patients using computational fluid dynamics (CFD) and discrete particle motion (DPM). Three main parameters, including airflow rate, drug dose, and particle size, affecting aerosol deposition in the lungs of asthma patients are examined. The highest deposition fraction (DF) is obtained at the flow rate of 45 L min−1, the drug dose of 200 μg·puff−1, and the particle diameter of 5 μm. The optimized combination of levels for the three parameters for maximum drug deposition is performed via the Taguchi method. The importance of the influencing factors rank as particle size > drug dose > flow rate. RSM reveals that the combination of 30 L min−1, 5 μm, 200 μg·puff− has the highest deposition fraction. In part, this research also studied the deposition of bioaerosols contaminated with the SAR-CoV-2 virus, and their lowest DF is 1.15%. The low DF of bioaerosols reduces the probability of the SAR-CoV-2 virus transmission.
AB - The deposition phenomenon of microparticle and SAR-CoV-2 laced bioaerosol in human airways is studied by Taguchi methods and response surface methodology (RSM). The data used herein is obtained from simulations of airflow dynamics and deposition fractions of drug particle aerosols in the downstream airways of asthma patients using computational fluid dynamics (CFD) and discrete particle motion (DPM). Three main parameters, including airflow rate, drug dose, and particle size, affecting aerosol deposition in the lungs of asthma patients are examined. The highest deposition fraction (DF) is obtained at the flow rate of 45 L min−1, the drug dose of 200 μg·puff−1, and the particle diameter of 5 μm. The optimized combination of levels for the three parameters for maximum drug deposition is performed via the Taguchi method. The importance of the influencing factors rank as particle size > drug dose > flow rate. RSM reveals that the combination of 30 L min−1, 5 μm, 200 μg·puff− has the highest deposition fraction. In part, this research also studied the deposition of bioaerosols contaminated with the SAR-CoV-2 virus, and their lowest DF is 1.15%. The low DF of bioaerosols reduces the probability of the SAR-CoV-2 virus transmission.
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U2 - 10.1016/j.envres.2021.110975
DO - 10.1016/j.envres.2021.110975
M3 - Article
C2 - 33689824
AN - SCOPUS:85102564007
SN - 0013-9351
VL - 197
JO - Environmental Research
JF - Environmental Research
M1 - 110975
ER -