Analysis of the analogues of aristolochic acid and aristolactam in the plant of Aristolochia genus by HPLC

Jenq Huei Jou, Chia Ying Li, Edward P. Schelonka, Chun Hua Lin, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

A facile reversed-phase HPLC method for the analysis of aristolochic acid (AA) and aristolactam (AL) analogues was developed and used for the quantitative determination and quality control of the traditional Chinese medicine. Homonymic Chinese crude drugs such as Stephania tetrandra and Aristolochia fanchi Clematis armandii and A. manshuriensis can be easily identified by this method. The quantitative determination of AAs and ALs in 12 species of Aristolochia (A. elegans, A. zollingeriana, A. cucurbitifolia, A. mollis, A. kaempferi, A. shimadii, A. heterophylla, A. debilis, A. foveolata, A. contorta, A. trilobata and A. odoratissima) has been investigated. The chromatograms obtained in this study can serve as fingerprints to identify plant species in the Aristolochia genus, thus avoiding incorrect identification of herbal ingredients in manufacturing traditional Chinese medicine.

Original languageEnglish
Pages (from-to)40-45
Number of pages6
JournalJournal of Food and Drug Analysis
Volume12
Issue number1
Publication statusPublished - 2004 Mar

All Science Journal Classification (ASJC) codes

  • Food Science
  • Pharmacology

Fingerprint Dive into the research topics of 'Analysis of the analogues of aristolochic acid and aristolactam in the plant of Aristolochia genus by HPLC'. Together they form a unique fingerprint.

Cite this