Analysis of the analogues of aristolochic acid and aristolactam in the plant of Aristolochia genus by HPLC

Jenq Huei Jou; Chia Ying Li; Edward P. Schelonka; Chun Hua Lin; Tian Shung Wu

Analysis of the analogues of aristolochic acid and aristolactam in the plant of Aristolochia genus by HPLC

Jenq Huei Jou, Chia Ying Li, Edward P. Schelonka, Chun Hua Lin, Tian Shung Wu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

A facile reversed-phase HPLC method for the analysis of aristolochic acid (AA) and aristolactam (AL) analogues was developed and used for the quantitative determination and quality control of the traditional Chinese medicine. Homonymic Chinese crude drugs such as Stephania tetrandra and Aristolochia fanchi Clematis armandii and A. manshuriensis can be easily identified by this method. The quantitative determination of AAs and ALs in 12 species of Aristolochia (A. elegans, A. zollingeriana, A. cucurbitifolia, A. mollis, A. kaempferi, A. shimadii, A. heterophylla, A. debilis, A. foveolata, A. contorta, A. trilobata and A. odoratissima) has been investigated. The chromatograms obtained in this study can serve as fingerprints to identify plant species in the Aristolochia genus, thus avoiding incorrect identification of herbal ingredients in manufacturing traditional Chinese medicine.

Original language	English
Pages (from-to)	40-45
Number of pages	6
Journal	Journal of Food and Drug Analysis
Volume	12
Issue number	1
Publication status	Published - 2004 Mar

All Science Journal Classification (ASJC) codes

Food Science
Pharmacology

Access to Document

Fingerprint Dive into the research topics of 'Analysis of the analogues of aristolochic acid and aristolactam in the plant of Aristolochia genus by HPLC'. Together they form a unique fingerprint.

Cite this

@article{a80caae274624f11a22bed2efd370803,

title = "Analysis of the analogues of aristolochic acid and aristolactam in the plant of Aristolochia genus by HPLC",

abstract = "A facile reversed-phase HPLC method for the analysis of aristolochic acid (AA) and aristolactam (AL) analogues was developed and used for the quantitative determination and quality control of the traditional Chinese medicine. Homonymic Chinese crude drugs such as Stephania tetrandra and Aristolochia fanchi Clematis armandii and A. manshuriensis can be easily identified by this method. The quantitative determination of AAs and ALs in 12 species of Aristolochia (A. elegans, A. zollingeriana, A. cucurbitifolia, A. mollis, A. kaempferi, A. shimadii, A. heterophylla, A. debilis, A. foveolata, A. contorta, A. trilobata and A. odoratissima) has been investigated. The chromatograms obtained in this study can serve as fingerprints to identify plant species in the Aristolochia genus, thus avoiding incorrect identification of herbal ingredients in manufacturing traditional Chinese medicine.",

author = "Jou, {Jenq Huei} and Li, {Chia Ying} and Schelonka, {Edward P.} and Lin, {Chun Hua} and Wu, {Tian Shung}",

year = "2004",

month = mar,

language = "English",

volume = "12",

pages = "40--45",

journal = "Journal of Food and Drug Analysis",

issn = "1021-9498",

publisher = "National Laboratories of Foods and Drugs",

number = "1",

}

TY - JOUR

T1 - Analysis of the analogues of aristolochic acid and aristolactam in the plant of Aristolochia genus by HPLC

AU - Jou, Jenq Huei

AU - Li, Chia Ying

AU - Schelonka, Edward P.

AU - Lin, Chun Hua

AU - Wu, Tian Shung

PY - 2004/3

Y1 - 2004/3

N2 - A facile reversed-phase HPLC method for the analysis of aristolochic acid (AA) and aristolactam (AL) analogues was developed and used for the quantitative determination and quality control of the traditional Chinese medicine. Homonymic Chinese crude drugs such as Stephania tetrandra and Aristolochia fanchi Clematis armandii and A. manshuriensis can be easily identified by this method. The quantitative determination of AAs and ALs in 12 species of Aristolochia (A. elegans, A. zollingeriana, A. cucurbitifolia, A. mollis, A. kaempferi, A. shimadii, A. heterophylla, A. debilis, A. foveolata, A. contorta, A. trilobata and A. odoratissima) has been investigated. The chromatograms obtained in this study can serve as fingerprints to identify plant species in the Aristolochia genus, thus avoiding incorrect identification of herbal ingredients in manufacturing traditional Chinese medicine.

AB - A facile reversed-phase HPLC method for the analysis of aristolochic acid (AA) and aristolactam (AL) analogues was developed and used for the quantitative determination and quality control of the traditional Chinese medicine. Homonymic Chinese crude drugs such as Stephania tetrandra and Aristolochia fanchi Clematis armandii and A. manshuriensis can be easily identified by this method. The quantitative determination of AAs and ALs in 12 species of Aristolochia (A. elegans, A. zollingeriana, A. cucurbitifolia, A. mollis, A. kaempferi, A. shimadii, A. heterophylla, A. debilis, A. foveolata, A. contorta, A. trilobata and A. odoratissima) has been investigated. The chromatograms obtained in this study can serve as fingerprints to identify plant species in the Aristolochia genus, thus avoiding incorrect identification of herbal ingredients in manufacturing traditional Chinese medicine.

UR - http://www.scopus.com/inward/record.url?scp=2542570910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542570910&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:2542570910

VL - 12

SP - 40

EP - 45

JO - Journal of Food and Drug Analysis

JF - Journal of Food and Drug Analysis

SN - 1021-9498

IS - 1

ER -