Androgen excess down-regulates connexin43 in a human granulosa cell line

Cheng Hsuan Wu; Jyuer Ger Yang; Jiann Jou Yang; Yueh Min Lin; Hong Der Tsai; Ching Yuang Lin; Pao Lin Kuo

doi:10.1016/j.fertnstert.2010.06.077

Androgen excess down-regulates connexin43 in a human granulosa cell line

Cheng Hsuan Wu, Jyuer Ger Yang, Jiann Jou Yang, Yueh Min Lin, Hong Der Tsai, Ching Yuang Lin, Pao Lin Kuo

Department of Obstetrics Gynecology

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients.

Original language	English
Pages (from-to)	2938-2941
Number of pages	4
Journal	Fertility and Sterility
Volume	94
Issue number	7
DOIs	https://doi.org/10.1016/j.fertnstert.2010.06.077
Publication status	Published - 2010 Dec

All Science Journal Classification (ASJC) codes

Reproductive Medicine
Obstetrics and Gynaecology

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10.1016/j.fertnstert.2010.06.077

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title = "Androgen excess down-regulates connexin43 in a human granulosa cell line",

abstract = "By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients.",

author = "Wu, {Cheng Hsuan} and Yang, {Jyuer Ger} and Yang, {Jiann Jou} and Lin, {Yueh Min} and Tsai, {Hong Der} and Lin, {Ching Yuang} and Kuo, {Pao Lin}",

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AU - Wu, Cheng Hsuan

AU - Yang, Jyuer Ger

AU - Yang, Jiann Jou

AU - Lin, Yueh Min

AU - Tsai, Hong Der

AU - Lin, Ching Yuang

AU - Kuo, Pao Lin

PY - 2010/12

Y1 - 2010/12

N2 - By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients.

AB - By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients.

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Androgen excess down-regulates connexin43 in a human granulosa cell line

Abstract

All Science Journal Classification (ASJC) codes

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