Androgen excess down-regulates connexin43 in a human granulosa cell line

Cheng Hsuan Wu, Jyuer Ger Yang, Jiann Jou Yang, Yueh Min Lin, Hong Der Tsai, Ching Yuang Lin, Pao Lin Kuo

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients.

Original languageEnglish
Pages (from-to)2938-2941
Number of pages4
JournalFertility and Sterility
Volume94
Issue number7
DOIs
Publication statusPublished - 2010 Dec

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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