Androgen excess down-regulates connexin43 in a human granulosa cell line

Cheng Hsuan Wu, Jyuer Ger Yang, Jiann Jou Yang, Yueh Min Lin, Hong Der Tsai, Ching Yuang Lin, Pao-Lin Kuo

Research output: Contribution to journal › Article

19 Citations (Scopus)

Abstract

By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients.

Original languageEnglish
Pages (from-to)2938-2941
Number of pages4
JournalFertility and Sterility
Volume94
Issue number7
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Connexin 43
Granulosa Cells
Androgens
Down-Regulation
Cell Line
Polycystic Ovary Syndrome
Gap Junctions
Androgen Receptors

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Wu, C. H., Yang, J. G., Yang, J. J., Lin, Y. M., Tsai, H. D., Lin, C. Y., & Kuo, P-L. (2010). Androgen excess down-regulates connexin43 in a human granulosa cell line. Fertility and Sterility, 94(7), 2938-2941. https://doi.org/10.1016/j.fertnstert.2010.06.077
Wu, Cheng Hsuan ; Yang, Jyuer Ger ; Yang, Jiann Jou ; Lin, Yueh Min ; Tsai, Hong Der ; Lin, Ching Yuang ; Kuo, Pao-Lin. / Androgen excess down-regulates connexin43 in a human granulosa cell line. In: Fertility and Sterility. 2010 ; Vol. 94, No. 7. pp. 2938-2941.
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Wu, CH, Yang, JG, Yang, JJ, Lin, YM, Tsai, HD, Lin, CY & Kuo, P-L 2010, 'Androgen excess down-regulates connexin43 in a human granulosa cell line', Fertility and Sterility, vol. 94, no. 7, pp. 2938-2941. https://doi.org/10.1016/j.fertnstert.2010.06.077

Androgen excess down-regulates connexin43 in a human granulosa cell line. / Wu, Cheng Hsuan; Yang, Jyuer Ger; Yang, Jiann Jou; Lin, Yueh Min; Tsai, Hong Der; Lin, Ching Yuang; Kuo, Pao-Lin.

In: Fertility and Sterility, Vol. 94, No. 7, 01.12.2010, p. 2938-2941.

Research output: Contribution to journal › Article

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Wu CH, Yang JG, Yang JJ, Lin YM, Tsai HD, Lin CY et al. Androgen excess down-regulates connexin43 in a human granulosa cell line. Fertility and Sterility. 2010 Dec 1;94(7):2938-2941. https://doi.org/10.1016/j.fertnstert.2010.06.077

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