TY - JOUR
T1 - Ankle–Brachial Index Predicts Long‐Term Renal Outcomes in Acute Stroke Patients
AU - Lee, Tsung Lin
AU - Chang, Yu Ming
AU - Liu, Chi Hung
AU - Su, Hui Chen
AU - Sung, Pi Shan
AU - Lin, Sheng Hsiang
AU - Chen, Chih Hung
N1 - Funding Information:
This work was supported by the Ministry of Science and Technology of Taiwan via contract MOST 108‐2321‐B‐006‐024‐MY2 and a grant from National Cheng Kung University Hospital (Grant number: NCKUH‐10803037, NCKUH‐10902039, NCKUH‐11102021). The funding source was not involved in any of the study processes or the writing of this manuscript. This research had no relationship with industry and pharmaceutical companies. We are grateful to the Biostatistics Consulting Center, National Cheng Kung University Hospital for providing us with statistical consulting services.
Funding Information:
Funding: This work was supported by the Ministry of Science and Technology of Taiwan via con‐ tract MOST 108‐2321‐B‐006‐024‐MY2 and a grant from National Cheng Kung University Hospital (Grant number: NCKUH‐10803037, NCKUH‐10902039, NCKUH‐11102021). The funding source was not involved in any of the study processes or the writing of this manuscript. This research had no relationship with industry and pharmaceutical companies.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/5
Y1 - 2022/5
N2 - Renal dysfunction is common after stroke. We aimed to investigate the clinical predictability of the ankle–brachial index (ABI) and brachial‐ankle pulse wave velocity (baPWV) on post-stroke renal deterioration. A total of 956 consecutive participants with acute ischemic stroke between 1 July 2016, and 31 December 2017 were enrolled and a final of 637 patients were recruited for final analysis. By using the group‐based trajectory model (GBTM), the patients’ renal function trajectories were grouped into the low, intermediate, and high categories (LC, IC, and HC). Significant deterioration in the slope was noted in the IC (p < 0.001) and LC (p = 0.002) groups but was nonsignificant in the HC (p = 0.998) group. Abnormal ABI (ABI ≤ 0.9) was independently related to LC (adjusted odds ratio: 2.40; 95% CI, 1.16–4.95; p = 0.019) and was also independently associated with increased risks of a ≥ 30% decline in eGFR (adjusted hazard ratio [aHR], 2.28; 95% CI, 1.29– 4.05; p = 0.005), a doubling of serum creatinine (aHR, 3.60; 95% CI, 1.93–8.34; p < 0.001) and ESRD (HR, 3.28; 95% CI, 1.23–8.74; p = 0.018). However, baPWV did not have a significant relationship with any of the renal outcomes. Patients with a lower ABI during acute stroke should receive regular renal function tests and should be closely monitored to improve poststroke renal care.
AB - Renal dysfunction is common after stroke. We aimed to investigate the clinical predictability of the ankle–brachial index (ABI) and brachial‐ankle pulse wave velocity (baPWV) on post-stroke renal deterioration. A total of 956 consecutive participants with acute ischemic stroke between 1 July 2016, and 31 December 2017 were enrolled and a final of 637 patients were recruited for final analysis. By using the group‐based trajectory model (GBTM), the patients’ renal function trajectories were grouped into the low, intermediate, and high categories (LC, IC, and HC). Significant deterioration in the slope was noted in the IC (p < 0.001) and LC (p = 0.002) groups but was nonsignificant in the HC (p = 0.998) group. Abnormal ABI (ABI ≤ 0.9) was independently related to LC (adjusted odds ratio: 2.40; 95% CI, 1.16–4.95; p = 0.019) and was also independently associated with increased risks of a ≥ 30% decline in eGFR (adjusted hazard ratio [aHR], 2.28; 95% CI, 1.29– 4.05; p = 0.005), a doubling of serum creatinine (aHR, 3.60; 95% CI, 1.93–8.34; p < 0.001) and ESRD (HR, 3.28; 95% CI, 1.23–8.74; p = 0.018). However, baPWV did not have a significant relationship with any of the renal outcomes. Patients with a lower ABI during acute stroke should receive regular renal function tests and should be closely monitored to improve poststroke renal care.
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U2 - 10.3390/healthcare10050913
DO - 10.3390/healthcare10050913
M3 - Article
AN - SCOPUS:85130629009
SN - 2227-9032
VL - 10
JO - Healthcare (Switzerland)
JF - Healthcare (Switzerland)
IS - 5
M1 - 913
ER -