Annoquinone-A, an antimicrobial and cytotoxic principle from Annona montana

Tian Shung Wu; Ting Ting Jong; Hsien Ju Tien; Chang Sheng Kuoh; Hiroshi Furukawa; Kuo Hsiung Lee

doi:10.1016/S0031-9422(00)82257-8

Annoquinone-A, an antimicrobial and cytotoxic principle from Annona montana

Tian Shung Wu, Ting Ting Jong, Hsien Ju Tien, Chang Sheng Kuoh, Hiroshi Furukawa, Kuo Hsiung Lee

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

A new naturally occurring phenanthrene-1,4-quinone, annoquinone-A, along with parietin (physcion) and β-sitostenone were isolated from the stem bark of Annona montana. The structure of annoquinone-A was elucidated by spectral methods and synthesis. Annoquinone-A demonstrated potent antimicrobial activity against Bacillus subtilis and Micrococcus luteus as well as cytotoxicity in the KB (ED₅₀ = 0.16 μg/ml) tissue culture assay. β-Sitostenone also showed significant cytotoxicity.

Original language	English
Pages (from-to)	1623-1625
Number of pages	3
Journal	Phytochemistry
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/S0031-9422(00)82257-8
Publication status	Published - 1987

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Plant Science
Horticulture

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title = "Annoquinone-A, an antimicrobial and cytotoxic principle from Annona montana",

abstract = "A new naturally occurring phenanthrene-1,4-quinone, annoquinone-A, along with parietin (physcion) and β-sitostenone were isolated from the stem bark of Annona montana. The structure of annoquinone-A was elucidated by spectral methods and synthesis. Annoquinone-A demonstrated potent antimicrobial activity against Bacillus subtilis and Micrococcus luteus as well as cytotoxicity in the KB (ED50 = 0.16 μg/ml) tissue culture assay. β-Sitostenone also showed significant cytotoxicity.",

author = "Wu, {Tian Shung} and Jong, {Ting Ting} and Tien, {Hsien Ju} and Kuoh, {Chang Sheng} and Hiroshi Furukawa and Lee, {Kuo Hsiung}",

year = "1987",

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T1 - Annoquinone-A, an antimicrobial and cytotoxic principle from Annona montana

AU - Wu, Tian Shung

AU - Jong, Ting Ting

AU - Tien, Hsien Ju

AU - Kuoh, Chang Sheng

AU - Furukawa, Hiroshi

AU - Lee, Kuo Hsiung

PY - 1987

Y1 - 1987

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AB - A new naturally occurring phenanthrene-1,4-quinone, annoquinone-A, along with parietin (physcion) and β-sitostenone were isolated from the stem bark of Annona montana. The structure of annoquinone-A was elucidated by spectral methods and synthesis. Annoquinone-A demonstrated potent antimicrobial activity against Bacillus subtilis and Micrococcus luteus as well as cytotoxicity in the KB (ED50 = 0.16 μg/ml) tissue culture assay. β-Sitostenone also showed significant cytotoxicity.

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JO - Phytochemistry

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