Annoquinone-A, an antimicrobial and cytotoxic principle from Annona montana

Tian Shung Wu, Ting Ting Jong, Hsien Ju Tien, Chang Sheng Kuoh, Hiroshi Furukawa, Kuo Hsiung Lee

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

A new naturally occurring phenanthrene-1,4-quinone, annoquinone-A, along with parietin (physcion) and β-sitostenone were isolated from the stem bark of Annona montana. The structure of annoquinone-A was elucidated by spectral methods and synthesis. Annoquinone-A demonstrated potent antimicrobial activity against Bacillus subtilis and Micrococcus luteus as well as cytotoxicity in the KB (ED50 = 0.16 μg/ml) tissue culture assay. β-Sitostenone also showed significant cytotoxicity.

Original languageEnglish
Pages (from-to)1623-1625
Number of pages3
JournalPhytochemistry
Volume26
Issue number6
DOIs
Publication statusPublished - 1987

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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