TY - JOUR
T1 - Antenatal corticosteroid therapy in late preterm delivery
T2 - a nationwide population-based retrospective study in Taiwan
AU - Liang, F. W.
AU - Tsai, H. F.
AU - Kuo, P. L.
AU - Tsai, P. Y.
N1 - Funding Information:
This study was funded and supported by grants from National Cheng Kung University Hospital (NCKUH-10606022) and from the Cheng Chen Foundation, Taiwan. The funders had no role in designing or conducting the study, in collecting or interpreting the data, or in the decision to submit the work for publication. We are grateful for the support of the HWDC of the Ministry of Health and Welfare of Taiwan. We are also grateful to the Health Data Science Centre, National Cheng Kung University Hospital, for providing administrative and technical assistance. We thank the researchers at the Department of Public Health, National Cheng Kung University, Taiwan, for their assistance with setting up the database.
Publisher Copyright:
© 2021 John Wiley & Sons Ltd.
PY - 2021/8
Y1 - 2021/8
N2 - Objective: To investigate whether antenatal corticosteroid therapy improves neonatal and maternal outcomes in late preterm delivery. Design: Population-based retrospective study. Setting: The linkages of Taiwan’s National Health Insurance Research Database, National Birth Reporting Database, and the Taiwan Maternal and Child Health Database. Population: All births at risk for late preterm deliveries in Taiwan between 2004 and 2011. Methods: For every birth at risk for late preterm delivery, five controls randomly matched by maternal and gestational ages and birthweight were included. A conditional logistic regression analysis was applied for risk estimation, with births without corticosteroids as the reference group. Odds ratios were adjusted for caesarean section, parity, sex, gestational hypertension and gestational diabetes mellitus. Main outcome measures: Neonatal outcomes, maternal outcomes and the utilisation of healthcare services. Results: The outcomes of 5745 women treated with corticosteroids between 34+0 weeks and 36+6 weeks of gestation were compared with those of 28 135 untreated controls. Compared with the controls, births from women administered corticosteroids reduced the need for continuous positive airway pressure, the number of neonatal intensive care unit admission, and the need for glucose administration, as well as the risk of neonatal respiratory distress, but increased the risk of neonatal sepsis and the number of outpatient visits. Conclusions: Antenatal corticosteroid therapy in women at risk of late preterm delivery may significantly reduce the need for respiratory support and glucose supply, and respiratory complication risk in neonates. Tweetable abstract: Antenatal corticosteroids in late preterm delivery reduced the risk of neonatal respiratory complications in Taiwan.
AB - Objective: To investigate whether antenatal corticosteroid therapy improves neonatal and maternal outcomes in late preterm delivery. Design: Population-based retrospective study. Setting: The linkages of Taiwan’s National Health Insurance Research Database, National Birth Reporting Database, and the Taiwan Maternal and Child Health Database. Population: All births at risk for late preterm deliveries in Taiwan between 2004 and 2011. Methods: For every birth at risk for late preterm delivery, five controls randomly matched by maternal and gestational ages and birthweight were included. A conditional logistic regression analysis was applied for risk estimation, with births without corticosteroids as the reference group. Odds ratios were adjusted for caesarean section, parity, sex, gestational hypertension and gestational diabetes mellitus. Main outcome measures: Neonatal outcomes, maternal outcomes and the utilisation of healthcare services. Results: The outcomes of 5745 women treated with corticosteroids between 34+0 weeks and 36+6 weeks of gestation were compared with those of 28 135 untreated controls. Compared with the controls, births from women administered corticosteroids reduced the need for continuous positive airway pressure, the number of neonatal intensive care unit admission, and the need for glucose administration, as well as the risk of neonatal respiratory distress, but increased the risk of neonatal sepsis and the number of outpatient visits. Conclusions: Antenatal corticosteroid therapy in women at risk of late preterm delivery may significantly reduce the need for respiratory support and glucose supply, and respiratory complication risk in neonates. Tweetable abstract: Antenatal corticosteroids in late preterm delivery reduced the risk of neonatal respiratory complications in Taiwan.
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U2 - 10.1111/1471-0528.16677
DO - 10.1111/1471-0528.16677
M3 - Article
C2 - 33629515
AN - SCOPUS:85102627885
VL - 128
SP - 1497
EP - 1502
JO - The Journal of obstetrics and gynaecology of the British Empire
JF - The Journal of obstetrics and gynaecology of the British Empire
SN - 1470-0328
IS - 9
ER -