Anterior gradient 2: A novel sensitive tumor marker for metastatic oral cancer

Yi Ting Chen; Chung Liang Ho; Po Ku Chen; Yuh Ling Chen; Chuan Fa Chang

doi:10.1016/j.canlet.2013.06.025

Anterior gradient 2: A novel sensitive tumor marker for metastatic oral cancer

Yi Ting Chen, Chung Liang Ho, Po Ku Chen, Yuh Ling Chen, Chuan Fa Chang

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 ( agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.

Original language	English
Pages (from-to)	270-278
Number of pages	9
Journal	Cancer Letters
Volume	339
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2013.06.025
Publication status	Published - 2013 Oct 10

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/j.canlet.2013.06.025

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@article{b7efc8edf3844554a82757ca3b1d0253,

title = "Anterior gradient 2: A novel sensitive tumor marker for metastatic oral cancer",

abstract = "The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 ( agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.",

author = "Chen, {Yi Ting} and Ho, {Chung Liang} and Chen, {Po Ku} and Chen, {Yuh Ling} and Chang, {Chuan Fa}",

note = "Funding Information: We are grateful for the support from the Tissue Bank and Bioinformatics Core Lab, Research Center of Clinical Medicine, National Cheng Kung University Hospital. Computational analyses and data mining were performed using the system provided by the Bioinformatics Core at the National Cheng Kung University. We are also grateful for the financial support from National Science Council Grant ( NSC 100-2321-B-006-009- , NSC 101-2321-B-006-008- ). ",

year = "2013",

month = oct,

day = "10",

doi = "10.1016/j.canlet.2013.06.025",

language = "English",

volume = "339",

pages = "270--278",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Anterior gradient 2

T2 - A novel sensitive tumor marker for metastatic oral cancer

AU - Chen, Yi Ting

AU - Ho, Chung Liang

AU - Chen, Po Ku

AU - Chen, Yuh Ling

AU - Chang, Chuan Fa

N1 - Funding Information: We are grateful for the support from the Tissue Bank and Bioinformatics Core Lab, Research Center of Clinical Medicine, National Cheng Kung University Hospital. Computational analyses and data mining were performed using the system provided by the Bioinformatics Core at the National Cheng Kung University. We are also grateful for the financial support from National Science Council Grant ( NSC 100-2321-B-006-009- , NSC 101-2321-B-006-008- ).

PY - 2013/10/10

Y1 - 2013/10/10

N2 - The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 ( agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.

AB - The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 ( agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.

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DO - 10.1016/j.canlet.2013.06.025

M3 - Article

C2 - 23834814

AN - SCOPUS:84883758354

SN - 0304-3835

VL - 339

SP - 270

EP - 278

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Anterior gradient 2: A novel sensitive tumor marker for metastatic oral cancer

Abstract

All Science Journal Classification (ASJC) codes

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