Abstract
The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 ( agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.
Original language | English |
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Pages (from-to) | 270-278 |
Number of pages | 9 |
Journal | Cancer Letters |
Volume | 339 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2013 Oct 10 |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research