Anterior gradient 2: A novel sensitive tumor marker for metastatic oral cancer

Yi Ting Chen, Chung Liang Ho, Po Ku Chen, Yuh Ling Chen, Chuan Fa Chang

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 ( agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.

Original languageEnglish
Pages (from-to)270-278
Number of pages9
JournalCancer Letters
Issue number2
Publication statusPublished - 2013 Oct 10

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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