TY - JOUR
T1 - Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica
AU - Ito, Chihiro
AU - Matsui, Takuya
AU - Takano, Makiko
AU - Wu, Tian Shung
AU - Itoigawa, Masataka
N1 - Publisher Copyright:
© 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/9/17
Y1 - 2018/9/17
N2 - Study of the chemical constituents of the roots of Plumbago zeylanica L. collected in Taiwan led to the isolation and identification of a new naphthoquinone dimer, plumzeylanone (1), along with eight known compounds (2–9). Nine naphthoquinones isolated from this plant were assayed for cell growth inhibition activity using NALM-6 (human B cell precursor leukaemia), A549 (human lung adenocarcinoma), Colo205 (human colorectal adenocarcinoma) and KB (human epidermoid carcinoma). Plumzeylanone (1), a novel plumbagin dimer, suppressed cell proliferation in only NALM-6 cells (IC50 3.98 μM). However, maritinone (9) showed strong inhibition of cell growth in all cell lines tested (0.12 < IC50 < 9.06 μM). This compound appeared to affect the cell cycle.
AB - Study of the chemical constituents of the roots of Plumbago zeylanica L. collected in Taiwan led to the isolation and identification of a new naphthoquinone dimer, plumzeylanone (1), along with eight known compounds (2–9). Nine naphthoquinones isolated from this plant were assayed for cell growth inhibition activity using NALM-6 (human B cell precursor leukaemia), A549 (human lung adenocarcinoma), Colo205 (human colorectal adenocarcinoma) and KB (human epidermoid carcinoma). Plumzeylanone (1), a novel plumbagin dimer, suppressed cell proliferation in only NALM-6 cells (IC50 3.98 μM). However, maritinone (9) showed strong inhibition of cell growth in all cell lines tested (0.12 < IC50 < 9.06 μM). This compound appeared to affect the cell cycle.
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U2 - 10.1080/14786419.2017.1366476
DO - 10.1080/14786419.2017.1366476
M3 - Article
C2 - 28823173
AN - SCOPUS:85028522349
SN - 1478-6419
VL - 32
SP - 2127
EP - 2132
JO - Natural Product Research
JF - Natural Product Research
IS - 18
ER -