TY - JOUR
T1 - Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica
AU - Ito, Chihiro
AU - Matsui, Takuya
AU - Takano, Makiko
AU - Wu, Tian Shung
AU - Itoigawa, Masataka
N1 - Funding Information:
This work was supported by JSPS KAKENHI [grant number 17K08353]. We wish to thank Prof C. S. Kouh for collecting, processing and posting the material. Thanks are also due to Dr Kenta Murotani, Aichi Medical University, for advice about statistical analysis. The authors would like to thank Mr Makoto Naruse in Central Research Laboratories for his contribution to flow cytometric analysis.
Funding Information:
This work was supported by JSPS KAKENHI [grant number 17K08353].
Publisher Copyright:
© 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/9/17
Y1 - 2018/9/17
N2 - Study of the chemical constituents of the roots of Plumbago zeylanica L. collected in Taiwan led to the isolation and identification of a new naphthoquinone dimer, plumzeylanone (1), along with eight known compounds (2–9). Nine naphthoquinones isolated from this plant were assayed for cell growth inhibition activity using NALM-6 (human B cell precursor leukaemia), A549 (human lung adenocarcinoma), Colo205 (human colorectal adenocarcinoma) and KB (human epidermoid carcinoma). Plumzeylanone (1), a novel plumbagin dimer, suppressed cell proliferation in only NALM-6 cells (IC50 3.98 μM). However, maritinone (9) showed strong inhibition of cell growth in all cell lines tested (0.12 < IC50 < 9.06 μM). This compound appeared to affect the cell cycle.
AB - Study of the chemical constituents of the roots of Plumbago zeylanica L. collected in Taiwan led to the isolation and identification of a new naphthoquinone dimer, plumzeylanone (1), along with eight known compounds (2–9). Nine naphthoquinones isolated from this plant were assayed for cell growth inhibition activity using NALM-6 (human B cell precursor leukaemia), A549 (human lung adenocarcinoma), Colo205 (human colorectal adenocarcinoma) and KB (human epidermoid carcinoma). Plumzeylanone (1), a novel plumbagin dimer, suppressed cell proliferation in only NALM-6 cells (IC50 3.98 μM). However, maritinone (9) showed strong inhibition of cell growth in all cell lines tested (0.12 < IC50 < 9.06 μM). This compound appeared to affect the cell cycle.
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U2 - 10.1080/14786419.2017.1366476
DO - 10.1080/14786419.2017.1366476
M3 - Article
C2 - 28823173
AN - SCOPUS:85028522349
SN - 1478-6419
VL - 32
SP - 2127
EP - 2132
JO - Natural Product Research
JF - Natural Product Research
IS - 18
ER -