Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica

Chihiro Ito, Takuya Matsui, Makiko Takano, Tian Shung Wu, Masataka Itoigawa

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7 Citations (Scopus)


Study of the chemical constituents of the roots of Plumbago zeylanica L. collected in Taiwan led to the isolation and identification of a new naphthoquinone dimer, plumzeylanone (1), along with eight known compounds (2–9). Nine naphthoquinones isolated from this plant were assayed for cell growth inhibition activity using NALM-6 (human B cell precursor leukaemia), A549 (human lung adenocarcinoma), Colo205 (human colorectal adenocarcinoma) and KB (human epidermoid carcinoma). Plumzeylanone (1), a novel plumbagin dimer, suppressed cell proliferation in only NALM-6 cells (IC50 3.98 μM). However, maritinone (9) showed strong inhibition of cell growth in all cell lines tested (0.12 < IC50 < 9.06 μM). This compound appeared to affect the cell cycle.

Original languageEnglish
Pages (from-to)2127-2132
Number of pages6
JournalNatural Product Research
Issue number18
Publication statusPublished - 2018 Sept 17

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry


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