Anti-hepatitis C virus dinorditerpenes from the roots of flueggea virosa

Chih Hua Chao; Ju Chien Cheng; De Yang Shen; Tian Shung Wu

doi:10.1021/np400528h

Anti-hepatitis C virus dinorditerpenes from the roots of flueggea virosa

Chih Hua Chao, Ju Chien Cheng, De Yang Shen, Tian Shung Wu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Along with four known terpenoids (1-4), eight new dinorditerpenes (5-12) were isolated and identified from the roots of Flueggea virosa. The absolute configurations of 4-6 were determined by the Mosher's method, and that of 5 was confirmed by single-crystal X-ray diffraction analysis. Using the hepatitis C virus cell culture infection system, compounds 1, 3, 11, and 12 exhibited significant anti-HCV activity with EC₅₀ values of 5.6, 5.0, 7.5, and 6.6 μM, respectively. Compounds 11 and 12 were nontoxic toward the tested Huh7.5 cell lines.

Original language	English
Pages (from-to)	22-28
Number of pages	7
Journal	Journal of Natural Products
Volume	77
Issue number	1
DOIs	https://doi.org/10.1021/np400528h
Publication status	Published - 2014 Jan 24

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np400528h

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title = "Anti-hepatitis C virus dinorditerpenes from the roots of flueggea virosa",

abstract = "Along with four known terpenoids (1-4), eight new dinorditerpenes (5-12) were isolated and identified from the roots of Flueggea virosa. The absolute configurations of 4-6 were determined by the Mosher's method, and that of 5 was confirmed by single-crystal X-ray diffraction analysis. Using the hepatitis C virus cell culture infection system, compounds 1, 3, 11, and 12 exhibited significant anti-HCV activity with EC50 values of 5.6, 5.0, 7.5, and 6.6 μM, respectively. Compounds 11 and 12 were nontoxic toward the tested Huh7.5 cell lines.",

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AU - Chao, Chih Hua

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AU - Wu, Tian Shung

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Y1 - 2014/1/24

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Anti-hepatitis C virus dinorditerpenes from the roots of flueggea virosa

Abstract

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