Anti-hepatitis C virus dinorditerpenes from the roots of flueggea virosa

Chih Hua Chao, Ju Chien Cheng, De Yang Shen, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Along with four known terpenoids (1-4), eight new dinorditerpenes (5-12) were isolated and identified from the roots of Flueggea virosa. The absolute configurations of 4-6 were determined by the Mosher's method, and that of 5 was confirmed by single-crystal X-ray diffraction analysis. Using the hepatitis C virus cell culture infection system, compounds 1, 3, 11, and 12 exhibited significant anti-HCV activity with EC50 values of 5.6, 5.0, 7.5, and 6.6 μM, respectively. Compounds 11 and 12 were nontoxic toward the tested Huh7.5 cell lines.

Original languageEnglish
Pages (from-to)22-28
Number of pages7
JournalJournal of Natural Products
Volume77
Issue number1
DOIs
Publication statusPublished - 2014 Jan 24

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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